Around 9% of the adult population in the world (463 million) suffer from diabetes mellitus.
Most of them (~ 90%) belong to type 2 diabetes mellitus (T2DM), which is a common chronic …

Genetic and environmental factors such as high-fat diet are involved in the development of
type 2 diabetes mellitus (T2DM). Cynomolgus monkey shares similar genetic makeup, tissue …

Objective Diabetes mellitus (DM) is a chronic disease characterized by hyperglycemia
resulting from defects in insulin secretion, insulin action, or both. The liver is a key organ …

Liver plays a key role in glucose metabolism and homeostasis, and impaired hepatic
glucose metabolism contributes to the development of type 2 diabetes. However, the precise …

Diabetes in the elderly increases cognitive impairment, but the underlying mechanisms are
still far from fully understood. A non-targeted metabolomics approach based on liquid …

Abstract The Goto-Kakizaki (GK) rat is an animal model of non-obese type 2 diabetes (T2D).
The GK rat was generated through the introduction of various genetic mutations from …

Non-obese, spontaneous, and genetically predisposed type 2 diabetic Chinese hamsters
exhibit metabolic abnormalities similar to those observed in human T2DM. Here, tandem …

The incidences of obesity and type 2 diabetes are rapidly increasing and have evolved into
a global epidemic. In this study, we analyzed the molecular effects of high-fat diet (HFD) …

Aims/introduction Streptozotocin (STZ) is a permanent diabetogenic compound and often
used in animal diabetes modeling. The aim of this study is to compare the liver transcriptome …

Insulin resistance occurs early in the disease process, preceding the development of type 2
diabetes. Therefore, the identification of molecules that contribute to insulin resistance and …