Small intestine proteomics coupled with serum metabolomics reveal disruption of amino acid metabolism in Chinese hamsters with type 2 diabetes mellitus

C Wang, J Yu, R Zhang, W Wang, Z Shi, Y Liu… - Journal of …, 2020 - Elsevier
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by hyperglycemia,
with metabolic disturbances resulting from defects in insulin secretion, insulin resistance …

Tandem mass tag-based proteomics analysis of type 2 diabetes mellitus with non-alcoholic fatty liver disease in mice treated with acupuncture

G Wang, M Li, S Yu, M Guan, S Ma, Z Zhong… - Bioscience …, 2022 - portlandpress.com
Objective: To explore the proteomics profiles of hepatocytes of mice treated with
acupuncture for type 2 diabetes mellitus (T2DM) with non-alcoholic fatty liver disease …

[HTML][HTML] Genome‑scale transcriptional analysis reveals key genes associated with the development of type II diabetes in mice

Y Zhang, D Han, P Yu, Q Huang… - Experimental and …, 2017 - spandidos-publications.com
Diabetes mellitus is one of the primary diseases that pose a threat to human health. The
focus of the present study is type II diabetes (T2D), which is caused by obesity and is the …

[HTML][HTML] Changes of liver transcriptome profiles following oxidative stress in streptozotocin-induced diabetes in mice

S Guo, X Mao, Y Yan, Y Zhang, L Ming - PeerJ, 2020 - peerj.com
Background Oxidative-stress (OS) was causal in the development of cell dysfunction and
insulin resistance. Streptozotocin (STZ) was an alkylation agent that increased reactive …

[HTML][HTML] PM2.5 induced liver lipid metabolic disorders in C57BL/6J mice

C Zhang, T Ma, C Liu, D Ma, J Wang, M Liu… - Frontiers in …, 2023 - frontiersin.org
PM2. 5 can cause adverse health effects via several pathways, such as inducing pulmonary
and systemic inflammation, penetration into circulation, and activation of the autonomic …

[HTML][HTML] Transcriptomic analysis of insulin-sensitive tissues from anti-diabetic drug treated ZDF rats, a T2DM animal model

YN Kim, S Kim, IY Kim, JH Shin, S Cho, SS Yi… - PLoS …, 2013 - journals.plos.org
Gene expression changes have been associated with type 2 diabetes mellitus (T2DM);
however, the alterations are not fully understood. We investigated the effects of anti-diabetic …

[HTML][HTML] Differentially expressed genes and enriched signaling pathways in the adipose tissue of obese people

Z Lu, L Meng, Z Sun, X Shi, W Shao, Y Zheng… - Frontiers in …, 2021 - frontiersin.org
As the prevalence of obesity increases, so does the occurrence of obesity-related
complications, such as cardiovascular and cerebrovascular diseases, diabetes, and some …

Metabolomics of Mice with Type 2 Diabetes and Nonalcoholic Fatty Liver Treated by Acupuncture

Y Guo, L Zhang, M Li, L Lin, F Xue… - International Journal …, 2024 - Wiley Online Library
Introduction. To investigate the effects of acupuncture on endogenous metabolites in the
liver of type 2 diabetes mellitus (T2DM) with nonalcoholic fatty liver disease (NAFLD) mice …

Key genes and co‐expression network analysis in the livers of type 2 diabetes patients

L Li, Z Pan, X Yang - Journal of diabetes investigation, 2019 - Wiley Online Library
Abstract Aims/Introduction The incidence of type 2 diabetes is increasing worldwide. Hepatic
insulin resistance and liver lipid accumulation contributes to type 2 diabetes development …

[HTML][HTML] Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats

M Sárközy, G Szűcs, V Fekete, M Pipicz, K Éder… - Cardiovascular …, 2016 - Springer
Background There is a spectacular rise in the global prevalence of type 2 diabetes mellitus
(T2DM) due to the worldwide obesity epidemic. However, a significant proportion of T2DM …