Dysfunctional visceral adipose tissue (VAT) in obesity is associated with type 2 diabetes
(DM) but underlying mechanisms remain unclear. Our objective in this discovery analysis …

Long noncoding RNAs (lncRNAs) influence the progression of almost all human diseases,
but the participation of lncRNAs in type 2 diabetes mellitus (T2DM) has not been fully …

Metabolomics represents an emerging discipline concerned with comprehensive
assessment of small molecule endogenous metabolites in biological systems and provides …

Endoplasmic reticulum (ER) is the principal organelle for protein synthesis, such as
hepatokines and transmembrane proteins, and is critical for maintaining physiological …

Liver plays a key role in maintaining glucose homeostasis and impaired hepatic glucose
metabolism is associated with type 2 diabetes. In the present study, we used RNA …

Metabolic syndrome (MetS) is a complex syndrome cluster of metabolic disorders, which
greatly increases the risks of diabetic and cardiovascular diseases. Although it has become …

DNA methylation is closely related to the occurrence and development of many diseases,
but its role in obesity is still unclear. This study aimed to find the potential differentially …

Abstract Type 2 diabetes (T2DM) is a complex multifactorial metabolic disorder that affects>
100 million individuals worldwide, yet the mechanisms involved in the development and …

Adipose tissue has a primary role in lipid and glucose metabolism as a storage site for fatty
acids, and also functions as an endocrine organ, producing large numbers of hormones and …

Diabetes mellitus (DM) can cause systemic metabolic disorders, but the impact of gender on
DM-related metabolic changes is rarely reported. Herein, we analyzed metabolic alterations …