Over the past three decades, tremendous progress has been made in elucidating
mechanisms underlying regenerative failure after spinal cord injury and in devising …

…… We may thus infer from what has been said that, in man as in laboratory animals, the
regenerative act commences, and may even attain a certain strength, on condition that the …

Regeneration of long axons after the spinal cord injury (SCI) will benefit patients with
extensive traumatic damage to the white matter pathways who experience intolerable …

Repairing the damaged spinal cord has for a long time eluded neuroscientists. Few other
achievements in neuroscience would have such a tremendous impact amongst the medical …

Traumatic injury to the peripheral and central nervous systems very often causes axotomy,
where an axon loses connections with its target resulting in loss of function. The axon …

Severe spinal cord injury (SCI) leads to devastating loss of neurological function below the
level of injury and adversely affects multiple body systems. Most basic research on SCI is …

A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which
dictates a battery of injury responses in axons and cell bodies. While some of these …

Spinal cord injury (SCI) is a traumatic event that can lead to permanent motor and sensory
deficits. After the initial trauma, axons of surviving neurons rapidly retract. While there may …

The use of genetically modified mice to study axon regeneration after spinal cord injury has
served as a useful in vivo model for both loss-of-function and gain-of-function analysis of …

With advances in genetic and imaging techniques, investigating axon regeneration after
spinal cord injury in vivo is becoming more common in the literature. However, there are …