Axons in the peripheral nervous system have the ability to repair themselves after damage,
whereas axons in the central nervous system are unable to do so. A common and important …

Although limited spontaneous recovery occurs after spinal cord injury (SCI), current
knowledge reveals that multiple forms of axon growth in spared axons can lead to circuit …

There are now numerous preclinical reports of various experimental treatments promoting
some functional recovery after spinal cord injury. Surprisingly, perhaps, the mechanisms that …

Current dogma states that meaningful recovery of function after spinal cord injury (SCI) will
likely require a combination of therapeutic interventions comprised of regenerative …

Central nervous system (CNS) injury, including stroke, spinal cord injury, and traumatic brain
injury, causes severe neurological symptoms such as sensory and motor deficits. Currently …

The field of spinal cord injury (SCI) research has experienced an immense evolution over
the past decades whereby results from preclinical studies have significantly facilitated our …

Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in
adults. Diverse molecules can partially facilitate or attenuate axon growth during …

Understanding the basic properties of how axons respond to injury in the mammalian central
nervous system (CNS) is of fundamental value for developing strategies to promote neural …

Neurons have a limited capacity to regenerate in the adult central nervous system (CNS).
The inability of damaged axons to re-establish original circuits results in permanent …

Central nervous system (CNS) has a limited regenerative capability, which makes it difficult
to repair after injury. Damage of axons from CNS, as in spinal cord injury, traumatic brain …