Platinum anticancer compounds are currently in widespread use for the treatment of
genitourinary and other tumors. In order to understand the mechanism of action of this …

Recent observations that several trans‐platinum complexes exhibit antitumor activity
including activity in cisplatin‐resistant tumor cells, violates the classical structure/activity …

We constructed two site-specifically modified nucleosomes containing an intrastrand cis-{Pt
(NH3) 2} 2+ 1, 3-d (GpTpG) cross-link, similar to one formed by the anticancer drugs …

Both cis‐[Pt (NH3) 2 (4‐Me‐Py) Cl]+ and trans‐[Pt (NH3) 2 (4‐Me‐Py) Cl]+ bind DNA
covalently at the N7 site of guanine residues forming mono‐dentate adducts. However, like …

The mechanism of action of platinum-based anticancer drugs such as cis-
diamminedichloroplatinum (II), or cisplatin, involves three early steps: cell entry, drug …

Instituí fúr Biophysik und physikalische Biochemie der Universitat Regensburg, D-8400
Regensburg, GFR Received June 4, 1986; Revised Manuscript Received September 26 …

Although both cis-diamminedichloroplatinum (II)(cisplatin or cis-DDP) and trans-
diamminedichloroplatinum (II) bind to DNA, only cis-DDP is widely used as a …

In order to form a covalent complex with DNA inside human cells, cisplatin has to overcome
the protective environment of a nucleosome, where DNA is complexed with histone proteins …

The reaction between cis-diamminedichloroplatinum (II)(cis-DDP) and L-cysteine was
examined at neutral pH at 37° C. The reaction proceeds through a Pt (NH3) 2 (cys) Cl …

The DNA interference pathways exhibited by cisplatin and related anticancer active metal
complexes have been extensively studied. Much less is known to what extent RNA …