Antitumor effects of cis-diamminedichloroplatinum (II)(cisplatin) and the clinical inactivity of
its trans isomer (transplatin) have been considered a paradigm for the classical structure …

During our earlier investigations we have observed a prominent preference of the linker
histone H1 for binding to a cis-platinated DNA (a synthetic fragment with global type of …

An antiproliferative platinum (II)–terpyridine complex bearing two piperidine substituents at
positions 2 and 2′(compound 1, hereafter) interacts non-covalently with DNA and induces …

Cisplatin and carboplatin are used successfully to treat various types of cancer. The drugs
target the nucleosomes of cancer cells and form intrastrand DNA cross-links that are located …

Since the early observations that cis-[PtCl2 (NH3) 2](cisplatin'), one of today's most
frequently used antitumour drugs (1), induces filamentous growth of Escherichia Coli (2) and …

In recent years there have been numerous major advances in the understanding of the
factors controlling all aspects of platinum binding to DNA and of the consequences of DNA …

Both cis-diamminedichloroplatinum (II)(cisplatin or cis-DDP) and trans-
diamminedichloroplatinum (II) form covalent adducts with DNA. However, only the cis isomer …

In order to shed light on the mechanism that underlies activity of bifunctional mononuclear Pt
II analogs of transplatin we examined in the present work a DNA binding mode of the analog …

Forty years after the discovery of the anticancer effects of cisplatin, scientists are still
pursuing the development of platinum complexes with improved properties regarding side …

Transplatinum planaramine complexes with carboxylate ligands as leaving groups, trans-[Pt
(O2CR) 2 (L)(L′)](L= L′= pyridine; L= NH3, L′= pyridine, isoquinoline, thiazole …