Background Catecholamines and β‐adrenergic receptors (β‐ARs) play an important role in
the regulation of cardiac tolerance to the impact of ischemia and reperfusion. This systematic …

Abstract The β3-AR (beta3-adrenergic receptor) is resistant to short-term agonist-promoted
desensitization and delivers a constant intracellular signal, making this receptor a potential …

The contribution of β3-AR activation towards ischemiareperfusion (IR) damage largely
depends on the disease stage, severity, experimental model as well as drug specificities …

This study examines the role of the β2‐adrenergic receptor (β2‐AR) in cardioprotection. The
β2‐AR couples to Gs and Gi proteins. Gs activates PKA, which phosphorylates the receptor …

Protein kinase A (PKA) activation has been implicated in early-phase ischemic
preconditioning. We recently found that during ischemia PKA activation causes inactivation …

Purpose: To evaluate the cardioprotective response of the pharmacological modulation of β-
adrenergic receptors (β-AR) in animal model of cardiac ischemia and reperfusion (CIR), in …

Beta-blockers have several beneficial cardiovascular effects in patients with hypertension,
angina pectoris, myocardial infarction, and congestive heart failure. In patients with …

X.-M. Gao, B.-H. Wang, E. Woodcock and X.-J. Du. Expression of Activeα1B-Adrenergic
Receptors in the Heart does not Alleviate Ischemic Reperfusion Injury. Journal of Molecular …

Selective stimulation of β 3 adrenergic-receptor (β3AR) has been shown to reduce infarct
size in a mouse model of myocardial ischemia/reperfusion. However, its functional long-term …

Stimulation of β-adrenergic receptors in the heart is the most effective endogenous way to
increase the mechanical performance of cardiac tissues to meet the requirements of a fight …