Background: Pyroptosis is an inflammatory programmed cell death accompanied by
activation of inflammasomes and maturation of pro-inflammatory cytokines interleukin-1β (IL …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1) has a major regulatory role in
cardiovascular disease. However, inhibiting PARP1 activity does not significantly improve …

Objective: Extensive studies have shown that ERS may be implicated in the pathogenesis of
DCM. We explored the therapeutic effects of lncRNAH19 on DCM and its effect on ERS …

Continuously generated hydrogen peroxide (H2O2) inhibits typical apoptosis and instead
initiates a caspase‐independent, apoptosis‐inducing factor (AIF)‐mediated pyknotic cell …

Background Endoplasmic reticulum (ER) stress-dependent apoptosis had been shown to
occur in the hearts of people with diabetes, although the exact mechanisms are unclear …

Sepsis is a life-threatening condition. Polydatin (PD), a small natural compound from
Polygonum cuspidatum, possesses antioxidant and anti-inflammatory properties. However …

Background: Atherosclerosis begins as local inflammation of vessels at sites of disturbed
flow, where low shear stress (LSS) leads to mechanical irritation and plaque development …

Poly (ADP-ribose) polymerase (PARP) is a nuclear enzyme that consumes NAD in response
to DNA strand breaks. The PARP inhibitor nicotinamide prevents NAD consumption and …

Objective To investigate the effect of siRNA against PTP-1B on neonatal rat cardiac myocyte
apoptosis induced by hypoxia-reoxygenation (H/R) and its molecular mechanisms. Methods …

Diabetic cardiomyopathy (DCM) is one of the main cardiac complications among diabetic
patients. According to previous studies, the pathogenesis of DCM is associated with …