Hyperactive poly (ADP-ribose) polymerases (PARP) promote ischemic heart failure (IHF)
after myocardial infarction (MI). However, the role of tankyrases (TNKSs), members of the …

The precise control of cardiomyocyte viability is imperative to combat myocardial ischemia‐
reperfusion injury (I/R), in which apoptosis and pyroptosis putatively contribute to the …

The deleterious effects of diabetes in the heart are increasingly attributed to inflammatory
signaling through the NLRP3 (NOD, LRR and PYD domains-containing protein 3) …

Poly (ADP‐ribosyl) ation reactions, carried out by poly (ADP‐ribose) polymerases
(PARPs/ARTDs), are reversible posttranslational modifications impacting on numerous …

Diabetic cardiomyopathy (DCM) is part of the most important causes of death from
cardiovascular disease. Perillaldehyde (PAE), a major component of the herb perilla, has …

Scope Diabetic cardiomyopathy is one of the most important cardiac complications
associated with diabetes. However, the mechanisms underlying diabetic cardiomyopathy …

The cardiotoxicity induced by doxorubicin is dose-dependent. The present study tested the
potential cardioprotective effect of Poly ADP Ribose Polymerase (PARP) pathway inhibitor …

Aims Diabetic cardiomyopathy (DC) is one of serious complications of diabetic patients. This
study investigated the biological function of activating transcription factor 4 (ATF4) in DC …

The elevated expression of poly (ADP-ribose) polymerase-1 (PARP1) and increased PARP1
activity, namely, poly (ADP-ribosyl) ation (PARylation), have been observed in cardiac …

Aims: This study aims to explore the efficacy of punicalagin (PG) on diabetic cardiomyopathy
(DCM), with a specific focus on the mechanisms underlying the effects of PG on …