Objectives To examine the risk of relapse and time to relapse after discontinuation of
antidepressants in patients with anxiety disorder who responded to antidepressants, and to …

BACKGROUND: We assessed the efficacy of continuation treatment with antidepressants in
a meta-analysis of relapse prevention studies in the five principal anxiety disorders, to …

Background Antidepressant drugs can promote remission from acute depressive episodes.
Our aim was to establish how long such treatments should be continued to prevent relapse …

BackgroundAfter remission, antidepressants are often taken long term to prevent depressive
relapse or recurrence. Whether psychological interventions can be a viable alternative or …

Objective: Continuation therapy with antidepressants is recommended for depressed
patients who have responded to initial treatment. We quantified its efficacy in preventing …

The aim of this article is to discuss the validity of relapse prevention trials and the issue of
withdrawal confounding in these trials. Recommendations for long-term antidepressant …

A significant clinical issue encountered after a successful acute major depressive disorder
(MDD) treatment is the relapse of depressive symptoms. Although continuing maintenance …

A substantial proportion of the burden of depression arises from its recurrent nature. The risk
of relapse after antidepressant medication (ADM) discontinuation is high but not uniform …

Background Several long‐term double‐blind placebo controlled trials have shown
prophylactic antidepressant therapy in unipolar depression. The goal of this work was to …

Background Understanding patterns of relapse in patients who respond to antidepressant
treatment can inform strategies for prevention of relapse. We aimed to identify distinct …