Objectives Considering the complementary nature of signalling mechanisms and the
therapeutic effects of nebivolol, a β1-adrenoreceptor antagonist, and valsartan, an …

We have recently illustrated that nebivolol can inhibit angiotensin II (Ang II)-mediated
signaling in cardiomyoblasts; however, to date, the detailed mechanism for the beneficial …

Here, we, for the first time, compared the cardioprotective effects of third-generation
vasodilating beta-blocker nebivolol (Neb) and conventional beta-blocker metoprolol (Met) …

Carvedilol, a third-generation and nonselective β-adrenoceptor antagonist, is a licensed
drug for treating patients suffering from heart failure in clinics. It has been shown that …

Background: Type II diabetes (T2D)-induced cardiomyocyte hypertrophy is closely linked to
the impairment of mitochondrial function. Berberine has been shown to be a promising effect …

Tissue damage in diabetes is at least partly due to elevated reactive oxygen species
production by the mitochondrial respiratory chain during hyperglycemia. Sustained …

Foci of fibrosis, footprints of cardiomyocyte necrosis, are scattered throughout the failing
myocardium and are a major component to its pathologic remodeling. Understanding …

Background: Oxidative stress contributes to adverse atrial remodeling in diabetes mellitus.
This remodeling can be prevented by the PPAR-γ agonist pioglitazone via its antioxidant …

Methods: In male SD rats (8-week-old), MI was used to induce HF by ligating the left anterior
descending branch of the coronary artery. In the Sham group, the coronary artery was …

Mitochondrial dysfunction triggered by increased reactive oxygen species (ROS) generation
is involved in the pathogenesis and development of cardiac hypertrophy. Nanoceria (cerium …