Angiotensin II–induced hypertension is associated with an increase in T-cell production of
interleukin-17A (IL-17A). Recently, we reported that IL-17A−/− mice exhibit blunted …

Hypertension is now considered as an inflammatory disease, and the kidney is a key end-
organ target. Experimental and clinical studies suggest that interleukin 17A (IL-17A) is a …

Abstract Purpose of Review To summarize key advances in our understanding of the role of
interleukin 17A (IL-17A) in the pathogenesis of hypertension and highlight important areas …

We have shown previously that T cells are required for the full development of angiotensin II–
induced hypertension. However, the specific subsets of T cells that are important in this …

T cells participate in angiotensin II (Ang II)–induced hypertension. However, the specific
subsets of T cells that are important in the end-organ damage are unknown. T-helper 17 …

Inflammatory cytokines play a major role in the pathophysiology of hypertension. The
authors previously showed that genetic deletion of interleukin (IL)-17A results in blunted …

Ample genetic and physiological evidence establishes that renal salt handling is a critical
regulator of blood pressure. Studies also establish a role for the immune system, T-cell …

An important link exists between hypertension and inflammation. Hypertensive patients
present elevated circulating levels of proinflammatory cytokines, including interleukin-17A …

Interstitial kidney inflammation is present in various nephritides in which serum interleukin
23 (IL-23) is elevated. Here we showed that murine and human renal tubular epithelial cells …

Being a member of the IL-17 family, comprising six structurally related ligands, IL-17A is a
cytokine, produced by multiple cell types, such as CD4+ αβ T cells, γδ T cells, natural killer …