Trends in HIV-1 pretreatment drug resistance and HIV-1 variant dynamics among antiretroviral therapy-naive Ethiopians from 2003 to 2018: a pooled sequence …

M Kiros, S Biset, B Gebremariam, GT Yalew… - Virology Journal, 2023 - Springer
Background Ethiopia is among the highly HIV-affected countries, with reported 12,000 and
12,000 AIDS-related deaths and incidents as per reports from 2021. Although the country …

Increased HIV-1 pretreatment drug resistance with consistent clade homogeneity among ART-naive HIV-1 infected individuals in Ethiopia

M Kiros, DH Alemayehu, E Geberekidan, A Mihret… - Retrovirology, 2020 - Springer
Background The development of pretreatment drug resistance (PDR) is becoming an
obstacle to the success of antiretroviral therapy (ART). Besides, data from developing …

Clade homogeneity and Pol gene polymorphisms in chronically HIV-1 infected antiretroviral treatment naive patients after the roll out of ART in Ethiopia

A Mulu, T Lange, UG Liebert, M Maier - BMC infectious diseases, 2014 - Springer
Background Despite the increasing use of antiretroviral treatment (ART) recent data on
frequency and pattern of drug resistance mutations in Ethiopia is not available. Furthermore …

Low incidence of HIV-1C acquired drug resistance 10 years after roll-out of antiretroviral therapy in Ethiopia: a prospective cohort study

A Mulu, M Maier, UG Liebert - PloS one, 2015 - journals.plos.org
The emergence of HIV-1 drug resistance mutations has mainly been linked to the duration
and composition of antiretroviral treatment (ART), as well as the level of adherence. This …

A viral genome wide association study and genotypic resistance testing in patients failing first line antiretroviral therapy in the first large countrywide Ethiopian HIV …

NF Telele, AW Kalu, S Gebre-Selassie, D Fekade… - BMC Infectious …, 2019 - Springer
Background Antiretroviral therapy (ART) was rolled-out in Ethiopia in 2005, but there are no
reports on outcome of ART and human immunodeficiency virus drug resistance (HIVDR) at …

Pre-Treatment HIV Drug Resistance and Genetic Diversity in Cameroon: Implications for First-Line Regimens

J Fokam, CA Chenwi, V Tala, D Takou, MM Santoro… - Viruses, 2023 - mdpi.com
The efficacy of first-line antiretroviral therapy (ART) may be hampered by the presence of
HIV drug resistance (HIVDR). We described HIV-1 pre-treatment drug resistance (PDR) …

Pretreatment drug resistance in a large countrywide Ethiopian HIV-1C cohort: a comparison of Sanger and high-throughput sequencing

NF Telele, AW Kalu, S Gebre-Selassie, D Fekade… - Scientific reports, 2018 - nature.com
Baseline plasma samples of 490 randomly selected antiretroviral therapy (ART) naïve
patients from seven hospitals participating in the first nationwide Ethiopian HIV-1 cohort …

Upward trends of acquired drug resistances in Ethiopian HIV-1C isolates: A decade longitudinal study

A Mulu, M Maier, UG Liebert - PloS one, 2017 - journals.plos.org
Background The emergence, accumulation and spread of HIV-1 drug resistance strains in
Africa could compromise the effectiveness of HIV treatment programs. This study was aimed …

[HTML][HTML] Evaluation of HIV-1 drug resistance among patients failing first-line antiretroviral therapy in Ethiopia

Y Getaneh, Q He, A Rashid, D Kassa, F Yi… - Journal of Global …, 2022 - Elsevier
Objectives The aim of this study was to evaluate HIV-1 drug resistance among patients
failing first-line antiretroviral therapy in Ethiopia. Methods A total of 699 adults infected with …

Trends in pretreatment HIV-1 drug resistance in antiretroviral therapy-naive adults in South Africa, 2000–2016: a pooled sequence analysis

B Chimukangara, RJ Lessells, SY Rhee… - …, 2019 - thelancet.com
Abstract Background South Africa has the largest public antiretroviral therapy (ART)
programme in the world. We assessed temporal trends in pretreatment HIV-1 drug …