Sex differences in CGRP regulation and function in the amygdala in a rat model of neuropathic pain
P Presto, V Neugebauer - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
The amygdala has emerged as a key player in the emotional response to pain and pain
modulation. The lateral and capsular regions of the central nucleus of the amygdala (CeA) …
modulation. The lateral and capsular regions of the central nucleus of the amygdala (CeA) …
Essential role of endogenous calcitonin gene‐related peptide in pain‐associated plasticity in the central amygdala
K Shinohara, AM Watabe, M Nagase… - European Journal of …, 2017 - Wiley Online Library
The role of the neuropeptide calcitonin gene‐related peptide (CGRP) is well established in
nociceptive behaviors. CGRP is highly expressed in the projection pathway from the …
nociceptive behaviors. CGRP is highly expressed in the projection pathway from the …
Facilitation of synaptic transmission and pain responses by CGRP in the amygdala of normal rats
JS Han, H Adwanikar, Z Li, G Ji… - Molecular …, 2010 - journals.sagepub.com
Calcitonin gene-related peptide (CGRP) plays an important role in peripheral and central
sensitization. CGRP also is a key molecule in the spino-parabrachial-amygdaloid pain …
sensitization. CGRP also is a key molecule in the spino-parabrachial-amygdaloid pain …
A female-specific role for calcitonin gene-related peptide (CGRP) in rodent pain models
C Paige, I Plasencia-Fernandez, M Kume… - Journal of …, 2022 - Soc Neuroscience
We aimed to investigate a sexually dimorphic role of calcitonin gene-related peptide (CGRP)
in rodent models of pain. Based on findings in migraine where CGRP has a preferential pain …
in rodent models of pain. Based on findings in migraine where CGRP has a preferential pain …
Critical role of calcitonin gene-related peptide 1 receptors in the amygdala in synaptic plasticity and pain behavior
JS Han, W Li, V Neugebauer - Journal of Neuroscience, 2005 - Soc Neuroscience
The role of neuropeptides in synaptic plasticity is less well understood than that of classical
transmitters such as glutamate. Here we report the importance of the G-protein-coupled …
transmitters such as glutamate. Here we report the importance of the G-protein-coupled …
Spinal CGRP1 receptors contribute to supraspinally organized pain behavior and pain-related sensitization of amygdala neurons
H Adwanikar, G Ji, W Li, H Doods, WD Willis… - Pain, 2007 - Elsevier
CGRP receptor activation has been implicated in peripheral and central sensitization. The
role of spinal CGRP receptors in supraspinal pain processing and higher integrated pain …
role of spinal CGRP receptors in supraspinal pain processing and higher integrated pain …
Potentiation of NMDA receptor-mediated synaptic transmission at the parabrachial-central amygdala synapses by CGRP in mice
Y Okutsu, Y Takahashi, M Nagase… - Molecular …, 2017 - journals.sagepub.com
The capsular part of the central amygdala (CeC) is called the “nociceptive amygdala,” as it
receives nociceptive information from various pathways, including monosynaptic input from …
receives nociceptive information from various pathways, including monosynaptic input from …
Contribution of Corticotropin-Releasing Factor Receptor 1 (CRF1) to Serotonin Receptor 5-HT2CR Function in Amygdala Neurons in a Neuropathic Pain Model
G Ji, V Neugebauer - International Journal of Molecular Sciences, 2019 - mdpi.com
The amygdala plays a key role in emotional-affective aspects of pain and in pain
modulation. The central nucleus (CeA) serves major amygdala output functions related to …
modulation. The central nucleus (CeA) serves major amygdala output functions related to …
Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior
R Powell, VA Young, KD Pryce, GD Sheehan… - Nature …, 2021 - nature.com
The advantage of locally applied anesthetics is that they are not associated with the many
adverse effects, including addiction liability, of systemically administered analgesics. This …
adverse effects, including addiction liability, of systemically administered analgesics. This …
Amygdala, neuropeptides, and chronic pain-related affective behaviors
Neuropeptides play important modulatory roles throughout the nervous system, functioning
as direct effectors or as interacting partners with other neuropeptide and neurotransmitter …
as direct effectors or as interacting partners with other neuropeptide and neurotransmitter …