Synaptic transmission controls brain activity and behaviors, including food intake. Leptin, an
adipocyte-derived hormone, acts on neurons located in the lateral hypothalamic area (LHA) …

BACKGROUND: Leptin is an adipocyte-derived cytokine that can act in the brain to suppress
feeding and maintain energy homeostasis. Additionally, leptin activates its receptors in the …

The leptin hormone is critical for normal food intake and metabolism. While leptin receptor
(Lepr) function has been well studied in the hypothalamus, the functional relevance of Lepr …

Leptin affects feeding, metabolism, and neuroendocrine status. It is now clearly established
that the hypothalamus coordinates these responses, though the specific brain regions …

The lateral hypothalamic area (LHA) acts in concert with the ventral tegmental area (VTA)
and other components of the mesolimbic dopamine (DA) system to control motivation …

BACKGROUND:: Overconsumption of calorically dense foods contributes substantially to the
current obesity epidemic. The adiposity hormone leptin has been identified as a potential …

Leptin receptors (LepRs) expressed in the midbrain contribute to the action of leptin on
feeding regulation. The midbrain neurons release a variety of neurotransmitters including …

Leptin acts on the ventral tegmental area (VTA) to modulate neuronal function and feeding
behavior in rats and mice. To identify the intracellular effectors of the leptin receptor (Lepr) …

The contribution of leptin-induced modulation of dopamine neurons to feeding behavior and
energy homeostasis remains unclear. Midbrain dopamine neurons regulate the reward …

Leptin target sites are found in several hypothalamic areas with dense populations of long
form leptin receptor (LepRb) expressing neurons which mediate important leptin actions …