Human bone marrow-derived mesenchymal stem cells (hBMSCs) are important for tissue
regeneration but their epigenetic regulation is not well understood. Here we investigate the …

Mesenchymal stem/stromal cells (MSCs) have been identified in almost all adult human
tissues and been used in numerous clinical trials for a variety of diseases. Studies have …

DNA methyltransferase (DNMT) inhibitors regulate target gene expression through
epigenetic modifications and these compounds have primarily been studied for cancer …

The application of physiological oxygen (physoxia) concentrations is becoming increasingly
commonplace within a mammalian stem cell culture. Human mesenchymal stem cells …

Mesenchymal stem cells (MSCs) are a heterogeneous population that can be isolated from
various tissues, including bone marrow, adipose tissue, umbilical cord blood, and …

Epigenetic modification is a crucial mechanism affecting the biological function of stem cells.
SETD4 is a histone methyltransferase, and its biological role in bone marrow mesenchymal …

Hematopoietic stem and progenitor cells (HPCs) can be maintained in vitro, but the vast
majority of their progeny loses stemness during culture. In this study, we compared DNA …

Stem cells have essential applications in in vitro tissue engineering or regenerative
medicine. However, there is still a need to understand more deeply the mechanisms of stem …

Bone marrow mesenchymal stem cells (BMSCs) nowadays are regarded as promising
candidates in cell‐based therapy for the regeneration of damaged bone tissues that are …

Mesenchymal stem cells (MSCs) have promising potential for bone tissue engineering in
bone healing and regeneration. They are regarded as such due to their capacity for self …