Synergistic effect of cannabidiol and transcutaneous electrical nerve stimulation on neuropathic and inflammatory pain in mice
Objectives Pain is the most common cause of seeking healthcare and the leading cause of
disability worldwide. Although cannabidiol and transcutaneous electrical nerve stimulation …
disability worldwide. Although cannabidiol and transcutaneous electrical nerve stimulation …
Cannabidiol induces systemic analgesia through activation of the PI3Kγ/nNOS/NO/KATP signaling pathway in neuropathic mice. A KATP channel S-nitrosylation …
DL de Almeida, RCM Ferreira, FC Fonseca… - Nitric Oxide, 2024 - Elsevier
Background Cannabidiol (CBD) is the second most abundant pharmacologically active
component present in Cannabis sp. Unlike Δ-9-tetrahydrocannabinol (THC), it has no …
component present in Cannabis sp. Unlike Δ-9-tetrahydrocannabinol (THC), it has no …
Cannabidiol effectively reverses mechanical and thermal allodynia, hyperalgesia, and anxious behaviors in a neuropathic pain model: Possible role of CB1 and …
The incidence of chronic pain is high in the general population and it is closely related to
anxiety disorders, which promote negative effects on the quality of life. The cannabinoid …
anxiety disorders, which promote negative effects on the quality of life. The cannabinoid …
Cannabidiol and endogenous opioid peptide-mediated mechanisms modulate antinociception induced by transcutaneous electrostimulation of the peripheral nervous …
TCT Gonçalves, AK Londe, RIP Albano… - Journal of the …, 2014 - Elsevier
Transcutaneous electrical nerve stimulation (TENS) is a non-pharmacological therapy for
the treatment of pain. The present work investigated the effect of cannabidiol, naloxone and …
the treatment of pain. The present work investigated the effect of cannabidiol, naloxone and …
Cannabidiol modulates chronic neuropathic pain aversion behavior by attenuation of neuroinflammation markers and neuronal activity in the corticolimbic circuit in …
GK Silva-Cardoso, W Lazarini-Lopes, EO Primini… - Behavioural Brain …, 2023 - Elsevier
Chronic neuropathic pain (CNP) is a vast world health problem often associated with the
somatosensory domain. This conceptualization is problematic because, unlike most other …
somatosensory domain. This conceptualization is problematic because, unlike most other …
Cannabidiol enhances the antinociceptive effects of morphine and attenuates opioid-induced tolerance in the chronic constriction injury model
CHA Jesus, MV Ferreira, AT Gasparin, ES Rosa… - Behavioural Brain …, 2022 - Elsevier
Neuropathic pain (NP) is a complex health problem that includes sensorial manifestations
such as evoked and ongoing pain. Cannabidiol (CBD) has shown potential in the treatment …
such as evoked and ongoing pain. Cannabidiol (CBD) has shown potential in the treatment …
[HTML][HTML] Insights on cannabidiol's antiallodynic and anxiolytic mechanisms of action in a model of neuropathic pain
M Schott - Pain Reports, 2019 - journals.lww.com
Recent studies have shown that cannabidiol (CBD) could have a great therapeutic potential
for treating disorders such as chronic pain and anxiety. In the target article, the authors …
for treating disorders such as chronic pain and anxiety. In the target article, the authors …
[HTML][HTML] Cannabidiol attenuates mechanical allodynia in streptozotocin-induced diabetic rats via serotonergic system activation through 5-HT1A receptors
CHA Jesus, DDB Redivo, AT Gasparin, BB Sotomaior… - Brain research, 2019 - Elsevier
Most diabetic patients describe moderate to severe pain symptoms whose pharmacological
treatment is palliative and poorly effective. Cannabidiol (CBD) has shown promising results …
treatment is palliative and poorly effective. Cannabidiol (CBD) has shown promising results …
Evaluating the efficacy of cannabidiol to manage surgically induced neuropathic pain in a preclinical rat model: Are T cells a sexually dimorphic target?
K Linher-Melville, G Singh - Canadian Journal of Pain, 2019 - Taylor & Francis
Background: Considering the poorly understood etiology and complex symptoms of chronic
neuropathic pain (NP), the lack of effective treatments, and sex-dependent differences in the …
neuropathic pain (NP), the lack of effective treatments, and sex-dependent differences in the …
Peripherally injected canabidiol reduces neuropathic pain in mice: Role of the 5-HT1A and TRPV1 receptors
DD Aguiar, C da Costa Oliveira, FCS Fonseca… - Biochemical and …, 2023 - Elsevier
Cannabidiol (CBD) is the most abundant non-psychoactive component found in plants of the
genus Cannabis. Its analgesic effect for the treatment of neuropathy has been widely …
genus Cannabis. Its analgesic effect for the treatment of neuropathy has been widely …