[HTML][HTML] How well do polygenic risk scores identify men at high risk for prostate cancer? Systematic review and meta-analysis
A Siltari, R Lönnerbro, K Pang, K Shiranov… - Clinical genitourinary …, 2023 - Elsevier
Objectives Genome-wide association studies have revealed over 200 genetic susceptibility
loci for prostate cancer (PCa). By combining them, polygenic risk scores (PRS) can be …
loci for prostate cancer (PCa). By combining them, polygenic risk scores (PRS) can be …
Validation of a prostate cancer polygenic risk score
Background Genome‐wide association studies have identified over 100 single‐nucleotide
polymorphisms (SNPs) associated with prostate cancer (PrCa), and polygenic risk scores …
polymorphisms (SNPs) associated with prostate cancer (PrCa), and polygenic risk scores …
A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease
A Amin Al Olama, Z Kote-Jarai… - Human molecular …, 2013 - academic.oup.com
Genome-wide association studies (GWAS) have identified multiple common genetic variants
associated with an increased risk of prostate cancer (PrCa), but these explain less than one …
associated with an increased risk of prostate cancer (PrCa), but these explain less than one …
Risk analysis of prostate cancer in PRACTICAL, a multinational consortium, using 25 known prostate cancer susceptibility loci
A Amin Al Olama, S Benlloch, AC Antoniou… - … , biomarkers & prevention, 2015 - AACR
Background: Genome-wide association studies have identified multiple genetic variants
associated with prostate cancer risk which explain a substantial proportion of familial relative …
associated with prostate cancer risk which explain a substantial proportion of familial relative …
[HTML][HTML] Evaluation of polygenic risk scores for prediction of prostate cancer in Korean men
JJ Oh, E Kim, E Woo, SH Song, JK Kim, H Lee… - Frontiers in …, 2020 - frontiersin.org
Aims The purpose of this study is to evaluate an aggregate influence of prostate cancer
(PCa) susceptibility variants on the development of PCa in Korean men by using the …
(PCa) susceptibility variants on the development of PCa in Korean men by using the …
[HTML][HTML] Polygenic risk score for genetic evaluation of prostate cancer risk in Asian populations: A narrative review
SH Song, SS Byun - Investigative and clinical urology, 2021 - ncbi.nlm.nih.gov
Decreasing costs of genetic testing and interest in disease inheritance has changed the
landscape of cancer prediction in prostate cancer (PCa), and guidelines now include …
landscape of cancer prediction in prostate cancer (PCa), and guidelines now include …
[HTML][HTML] Clinical validity and utility of genetic risk scores in prostate cancer
Current issues related to prostate cancer (PCa) clinical care (eg, over-screening, over-
diagnosis, and over-treatment of nonaggressive PCa) call for risk assessment tools that can …
diagnosis, and over-treatment of nonaggressive PCa) call for risk assessment tools that can …
Polygenic risk score in prostate cancer
JJ Oh, SK Hong - Current Opinion in Urology, 2022 - journals.lww.com
Emerging data from several studies regarding PRS in PCa could be the solution to adding
predictive value to PCa risk estimation. Although commercial markers are available …
predictive value to PCa risk estimation. Although commercial markers are available …
[HTML][HTML] Clinical features of prostate cancer by polygenic risk score
Genome-wide association studies have identified more than 290 single nucleotide variants
(SNVs) associated with prostate cancer. These SNVs can be combined to generate a …
(SNVs) associated with prostate cancer. These SNVs can be combined to generate a …
A systematic review of replication studies of prostate cancer susceptibility genetic variants in high-risk men originally identified from genome-wide association studies
MB Ishak, VN Giri - Cancer epidemiology, biomarkers & prevention, 2011 - AACR
Background: Several prostate cancer genome-wide association studies (GWAS) have
identified risk-associated genetic variants primarily in populations of European descent …
identified risk-associated genetic variants primarily in populations of European descent …