Whole-genome and transcriptome sequencing of prostate cancer identify new genetic alterations driving disease progression
Background Global disparities in prostate cancer (PCa) incidence highlight the urgent need
to identify genomic abnormalities in prostate tumors in different ethnic populations including …
to identify genomic abnormalities in prostate tumors in different ethnic populations including …
Genome-wide interrogation of structural variation reveals novel African-specific prostate cancer oncogenic drivers
Background African ancestry is a significant risk factor for advanced prostate cancer (PCa).
Mortality rates in sub-Saharan Africa are 2.5-fold greater than global averages. However, the …
Mortality rates in sub-Saharan Africa are 2.5-fold greater than global averages. However, the …
Whole-genome sequencing reveals elevated tumor mutational burden and initiating driver mutations in African men with treatment-naïve, high-risk prostate cancer
African-American men are more likely than any other racial group to die from prostate
cancer. The contribution of acquired genomic variation to this racial disparity is largely …
cancer. The contribution of acquired genomic variation to this racial disparity is largely …
Prospective genomic profiling of prostate cancer across disease states reveals germline and somatic alterations that may affect clinical decision making
Purpose A long natural history and a predominant osseous pattern of metastatic spread are
impediments to the adoption of precision medicine in patients with prostate cancer. To …
impediments to the adoption of precision medicine in patients with prostate cancer. To …
Integration of copy number and transcriptomics provides risk stratification in prostate cancer: a discovery and validation cohort study
Background Understanding the heterogeneous genotypes and phenotypes of prostate
cancer is fundamental to improving the way we treat this disease. As yet, there are no …
cancer is fundamental to improving the way we treat this disease. As yet, there are no …
Clinical variability and molecular heterogeneity in prostate cancer
J Shoag, CE Barbieri - Asian journal of andrology, 2016 - journals.lww.com
Prostate cancer is a clinically heterogeneous disease, with some men having indolent
disease that can safely be observed, while others have aggressive, lethal disease. Over the …
disease that can safely be observed, while others have aggressive, lethal disease. Over the …
Integrative comparison of the genomic and transcriptomic landscape between prostate cancer patients of predominantly African or European genetic ancestry
Men of predominantly African Ancestry (AA) have higher prostate cancer (CaP) incidence
and worse survival than men of predominantly European Ancestry (EA). While …
and worse survival than men of predominantly European Ancestry (EA). While …
Heterogeneity in the inter-tumor transcriptome of high risk prostate cancer
Background Genomic analyses of hundreds of prostate tumors have defined a diverse
landscape of mutations and genome rearrangements, but the transcriptomic effect of this …
landscape of mutations and genome rearrangements, but the transcriptomic effect of this …
Genomic profiling reveals alternative genetic pathways of prostate tumorigenesis
J Lapointe, C Li, CP Giacomini, K Salari, S Huang… - Cancer research, 2007 - AACR
Prostate cancer is clinically heterogeneous, ranging from indolent to lethal disease.
Expression profiling previously defined three subtypes of prostate cancer, one (subtype-1) …
Expression profiling previously defined three subtypes of prostate cancer, one (subtype-1) …
Genomic profiling of prostate cancers from men with African and European ancestry
Abstract Purpose: African American (AFR) men have the highest mortality rate from prostate
cancer (PCa) compared with men of other racial/ancestral groups. Differences in the …
cancer (PCa) compared with men of other racial/ancestral groups. Differences in the …