Objective: The present investigation was aimed to overcome the limitations and to enhance
the incorporation of the hydrophobic drug into polymeric nanoparticles and characterize the …

Objectives: Camptothecin is an anti-cancer drug widely used for treating colon cancer. Oral
delivery of camptothecin is limited by low bioavailability and gastrointestinal toxicity. In order …

Objectives: The present investigation was aimed to fabricate Camptothecin loaded Poly
(Methacyclic acid-co-methyl-methyacrylate) nanoparticles to characterize the prepared …

The aim of this study was to prepare small-molecule camptothecin (CPT) prodrugs and
evaluate their effectiveness in colorectal carcinoma therapy. Prodrug nanoparticles (NPs) …

The investigation was aimed at designing pH-sensitive, polymeric nanoparticles of
curcumin, a natural anti-cancer agent, for the treatment of colon cancer. The objective was to …

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the world and is
the second leading cause of cancer related deaths. New cases are increasingly diagnosed …

Most popular cancer targeted drug delivery system is polymeric nanoparticles, and it is used
as a drug carrier which represents a marvellous path for cancer therapy. Polymeric …

Oral administration of pH sensitive/stimuli responsive nanoparticles are gaining importance
because of the limited side effects, minimum dose and controlled drug release. The …

In attempt to overcome the problem of low water solubility and severe toxicity of
camptothecin (CPT) after intravenous administration, a novel drug carrier system based on …

Ethyl-10-hydroxycamptothecin (SN-38) is 1000 times more cytotoxic than its prodrug
Irinotecan hydrochloride (CPT-11). It is not used therapeutically because of its insolubility in …