The first culture media designed specifically to support development of the preimplantation
mouse embryo were formulated over 50 years ago and were based on balanced salt …

Since the inception of modern embryo culture media over 50 years ago there have been
significant developments in culture systems for the mammalian preimplantation embryo …

There are several treatises on the composition of embryo culture media and the role of
specific medium components in supporting mammalian embryo development in vitro (1–3). It …

Systematic studies of mouse embryo culture beginning in 1949 led to an understanding of
essential medium components for early mammalian embryos, and embryo culture from the …

Considerable advances in media development for the culture of preimplantation mammalian
embryos have been made since mouse embryos were first cultured and successfully …

Single embryo culture is suboptimal compared with group culture, but necessary for embryo
monitoring, and culture systems should be improved for single embryos. Pronucleate mouse …

The postimplantation embryos of rodents have been particularlyconvenient to study in
culture using the whole embryo culture (WEC) system developed by New. Two serious …

Abstract Development of preimplantation embryos, from fertilization to hatched-blastocyst
stage, has been a challenging task, regardless of the mammalian species being studied …

Although the mouse is widely used as an animal model for the in vitro culture of human
preimplantation embryos, arguments can be made for the validity of many domestic species …

Mammalian preimplantation embryos normally develop within the protected environment of
the female reproductive tract, which virtually precludes studies on embryogenesis in situ …