We examined the DNA methylation pathway in an autochthonous murine prostate cancer
model, transgenic adenocarcinoma of mouse prostate (TRAMP). We observed that …

We analyzed DNA methyltransferase (Dnmt) protein expression and DNA methylation
patterns during four progressive stages of prostate cancer in the transgenic adenocarcinoma …

Aberrant DNA methylation plays a significant role in nearly all human cancers and may
contribute to disease progression to advanced phenotypes. Study of advanced prostate …

Previous studies have shown that tumor progression in the transgenic adenocarcinoma of
mouse prostate (TRAMP) model is characterized by global DNA hypomethylation initiated …

Transcriptional silencing of tumor suppressor genes by DNA methylation plays an important
role in tumorigenesis. These aberrant epigenetic modifications may be mediated in part by …

Prostate cancer is the most common malignancy and the second leading cause of cancer
death among men in the United States. There are three well-established risk factors for …

Background DNA methylation has been linked to genome regulation and dysregulation in
health and disease respectively, and methods for characterizing genomic DNA methylation …

Background: Prostate cancer (PCa) harbors a myriad of genomic and epigenetic defects.
Cytosine methylation of CpG-rich promoter DNA is an important mechanism of epigenetic …

Epigenetic alterations contribute significantly to the development and progression of
prostate cancer, the most prevalent malignant tumor in males of Western industrialized …

Background Despite the significant global loss of DNA hydroxymethylation marks in prostate
cancer tissues, the locus-specific role of hydroxymethylation in prostate tumorigenesis is …