The human-specific tropism of Human Immunodeficiency Virus Type 1 (HIV-1) has
complicated the development of a macaque model of HIV-1 infection/AIDS that is suitable for …

Macaque monkeys serve as important animal models for understanding the pathogenesis of
lentiviral infections. Since human immunodeficiency virus type 1 (HIV-1) hardly replicates in …

HIV-1 is strictly adapted to humans, and cause disease-inducing persistent infection only in
humans. We have generated a series of macaque-tropic HIV-1 (HIV-1mt) to establish non …

The lack of a primate model that utilizes HIV-1 as the challenge virus is an impediment to
AIDS research; existing models generally employ simian viruses that are divergent from HIV …

The expression of xenogeneic TRIM5α proteins can restrict infection in various
retrovirus/host cell pairings. Previously, we have shown that African green monkey TRIM5α …

Simian immunodeficiency viruses of sooty mangabeys (SIVsm) are the source of multiple,
successful cross-species transmissions, having given rise to HIV-2 in humans, SIVmac in …

Diversification of antiretroviral factors during host evolution has erected formidable barriers
to cross-species retrovirus transmission. This phenomenon likely protects humans from …

ABSTRACT Among Old World monkeys, pig-tailed macaques (Pt) are uniquely susceptible
to human immunodeficiency virus type 1 (HIV-1), although the infection does not persist. We …

Human immunodeficiency virus type 1 (HIV-1) replication in macaque cells is restricted
mainly by antiviral cellular APOBEC3, TRIM5α/TRIM5CypA, and tetherin proteins. For basic …

The replication of human immunodeficiency type-1 (HIV-1) is restricted in macaque cells, in
part due to host factors that provide intrinsic immunity after entry. Here we show that a …