ABSTRACT TRIM5α is a natural resistance factor that binds retroviral capsid proteins and
restricts virus replication. The B30. 2/SPRY domain of TRIM5α is polymorphic in rhesus …

TRIM5α provides a cytoplasmic block to retroviral infection, and orthologs encoded by some
primates are active against HIV. Here, we present an evolutionary comparison of the TRIM5 …

Old World monkey TRIM5α targets incoming human immunodeficiency virus type 1 (HIV-1)
viral capsid, whereas the apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like …

Host cell barriers to the early phase of immunodeficiency virus replication explain the current
distribution of these viruses among human and non-human primate species,,,. Human …

Primate genomes contain a large number of endogenous retroviruses and encode
evolutionarily dynamic proteins that provide intrinsic immunity to retroviral infections. We …

Tripartite motif-containing 5 isoform-α (TRIM5α), a host restriction factor, blocks infection of
some retroviruses at a post-entry, pre-integration stage in a species-specific manner. A …

Human immunodeficiency virus type 1 (HIV-1) does not replicate in primary cells of New
World primates. To better understand this restriction, we expressed owl monkey (Aotus …

The strategy of all retroviral infections is based on establishing an equilibrium between virus
replication and proviral latency in the infected host. The human immunodeficiency virus‐type …

Objective: In Old World monkeys, the tripartite motif 5α (TRIM5α) protein confers resistance
to HIV-1 infection following virus entry into host cells. However, the pig-tailed macaque …

Retroviral capsid recognition by Trim5 blocks productive infection. Rhesus macaques harbor
three functionally distinct Trim5 alleles: Trim5αQ, Trim5αTFP and Trim5CypA. Despite the …