A novel fusion gene, TRIM5-Cyclophilin A in the pig-tailed macaque determines its susceptibility to HIV-1 infection
Objective: In Old World monkeys, the tripartite motif 5α (TRIM5α) protein confers resistance
to HIV-1 infection following virus entry into host cells. However, the pig-tailed macaque …
to HIV-1 infection following virus entry into host cells. However, the pig-tailed macaque …
Gain-of-sensitivity mutations in a Trim5-resistant primary isolate of pathogenic SIV identify two independent conserved determinants of Trim5α specificity
KR McCarthy, AG Schmidt, A Kirmaier… - PLoS …, 2013 - journals.plos.org
Retroviral capsid recognition by Trim5 blocks productive infection. Rhesus macaques harbor
three functionally distinct Trim5 alleles: Trim5αQ, Trim5αTFP and Trim5CypA. Despite the …
three functionally distinct Trim5 alleles: Trim5αQ, Trim5αTFP and Trim5CypA. Despite the …
Generation of HIV-1 derivatives that productively infect macaque monkey lymphoid cells
K Kamada, T Igarashi, MA Martin… - Proceedings of the …, 2006 - National Acad Sciences
The narrow host range of human immunodeficiency virus type 1 (HIV-1) is caused in part by
innate cellular factors such as apolipoprotein B mRNA-editing enzyme-catalytic polypeptide …
innate cellular factors such as apolipoprotein B mRNA-editing enzyme-catalytic polypeptide …
Tissue-specific restriction of cyclophilin A-independent HIV-1-and SIV-derived lentiviral vectors
CA Kahl, PM Cannon, J Oldenburg, AF Tarantal… - Gene therapy, 2008 - nature.com
The host factor α isoform of the tripartite motif 5 (TRIM5α) restricts human immunodeficiency
virus type 1 (HIV-1) infection in certain non-human primate species. Restriction of HIV-1 is …
virus type 1 (HIV-1) infection in certain non-human primate species. Restriction of HIV-1 is …
Modification of a loop sequence between α-helices 6 and 7 of virus capsid (CA) protein in a human immunodeficiency virus type 1 (HIV-1) derivative that has simian …
A Kuroishi, A Saito, Y Shingai, T Shioda, M Nomaguchi… - Retrovirology, 2009 - Springer
Background Human immunodeficiency virus type 1 (HIV-1) productively infects only humans
and chimpanzees but not cynomolgus or rhesus monkeys while simian immunodeficiency …
and chimpanzees but not cynomolgus or rhesus monkeys while simian immunodeficiency …
Adaptation to the interferon-induced antiviral state by human and simian immunodeficiency viruses
J Bitzegeio, M Sampias, PD Bieniasz… - Journal of …, 2013 - Am Soc Microbiol
The production of type I interferon (IFN) is an early host response to different infectious
agents leading to the induction of hundreds of IFN-stimulated genes (ISGs). The roles of …
agents leading to the induction of hundreds of IFN-stimulated genes (ISGs). The roles of …
Adaptation of subtype a human immunodeficiency virus type 1 envelope to pig-tailed macaque cells
D Humes, J Overbaugh - Journal of virology, 2011 - Am Soc Microbiol
The relevance of simian/human immunodeficiency virus (SHIV) infection of macaques to HIV-
1 infection in humans depends on how closely SHIVs mimic HIV-1 transmission …
1 infection in humans depends on how closely SHIVs mimic HIV-1 transmission …
Functional Cure of SIVagm Infection in Rhesus Macaques Results in Complete Recovery of CD4+ T Cells and Is Reverted by CD8+ Cell Depletion
I Pandrea, T Gaufin, R Gautam, J Kristoff… - PLoS …, 2011 - journals.plos.org
Understanding the mechanism of infection control in elite controllers (EC) may shed light on
the correlates of control of disease progression in HIV infection. However, limitations have …
the correlates of control of disease progression in HIV infection. However, limitations have …
Lack of endogenous TRIM5α-mediated restriction in rhesus macaque dendritic cells
NJ Arhel, S Nisole, L Carthagena… - Blood, The Journal …, 2008 - ashpublications.org
Rhesus macaques are resistant to infection by HIV-1 as a result of an innate cellular
restriction mechanism attributable to the expression of rhTRIM5α, a member of the large …
restriction mechanism attributable to the expression of rhTRIM5α, a member of the large …
Stably expressed APOBEC3H forms a barrier for cross-species transmission of simian immunodeficiency virus of chimpanzee to humans
APOBEC3s (A3s) are potent restriction factors of human immunodeficiency virus type
1/simian immunodeficiency viruses (HIV-1/SIV), and can repress cross-species …
1/simian immunodeficiency viruses (HIV-1/SIV), and can repress cross-species …