Retroviruses have an intricate life cycle. There is much to be learned from studying retrovirus-
host interactions. Among retroviruses, the primate lentiviruses have one of the more complex …

Human immunodeficiency virus type 1 (HIV‐1) shows a very narrow host range limited to
humans and chimpanzees. Experimentally, HIV‐1 does not infect Old World monkeys, such …

Human immunodeficiency virus type 1 (HIV-1)-based lentiviral vectors are indispensable
tools for gene engineering in mammalian cells. Conversely, lentiviral vector transduction is …

ABSTRACT Lv1/TRIM5α (tripartite motif 5α) has recently emerged as an important factor
influencing species-specific permissivity to retroviral infection in a range of primates …

Background HIV-2, which was transmitted to humans from a distant primate species (sooty
mangabey), differs remarkably from HIV-1 in its infectivity, transmissibility and pathogenicity …

Description: The lack of appropriate animal models that utilizes HIV-1 as the challenge virus
is a major impediment to HIV/AIDS research. A major reason underlying the inability of HIV-1 …

Extensive studies on HIV-1 have led to the discovery of a variety of structurally and
functionally diverse innate defense factors that target various steps of the retroviral …

TRIM5 proteins constitute a class of restriction factors that prevent host cell infection by
retroviruses from different species. TRIM5α restricts retroviral infection early after viral entry …

Human immunodeficiency virus type 1 (HIV-1) vectors transduce rhesus blood cells poorly
due to a species-specific block by TRIM5α and APOBEC3G, which target HIV-1 capsid and …

The tripartite motif 5 protein (TRIM5) has been extensively studied in view of its ability to
restrict retroviruses in mammalian hosts. The B30. 2 domain, encoded by exon 8 of TRIM5 …