Background: Cancer therapeutics have a low success rate in clinical trials. An
interdisciplinary approach is needed to translate basic, clinical, and remote fields of …

In this article, we briefly summarized evidence that cellular phosphate burden from
phosphate toxicity is a pathophysiological determinant of cancer cell growth. Tumor cells …

The importance of phosphate homeostasis in chronic kidney disease (CKD) has been
recognized for decades, but novel insights—which are frequently relevant to everyday …

Inorganic phosphate (Pi) is an essential mineral required for diverse cellular processes.
Recent genetic and dietary experiments in animal models indicate that Pi may be toxic to a …

Background Phosphate intake has increased in the last decades due to a higher
consumption of processed foods. This higher intake is detrimental for patients with chronic …

Maintenance of phosphate balance is essential for life, and mammals have developed a
sophisticated system to regulate phosphate homeostasis over the course of evolution …

Population-based studies have shown that most patients with advanced chronic kidney
disease (CKD) do not have optimal phosphate levels. Meta-analyses suggest that there is a …

The control of hyperphosphatemia is key to the management of chronic kidney disease
mineral and bone disorder. Dietary restriction of phosphorus is essential to control …

A complex system of endocrine and paracrine signals exists to control phosphate balance.
Dysregulation of these systems in patients with chronic kidney disease has serious clinical …

Phosphorus is a vital nutrient, but disturbances in phosphorus homeostasis are central to
chronic kidney disease-mineral and bone disorder. To minimize disturbances, traditional …