With advances in genetic and imaging techniques, investigating axon regeneration after
spinal cord injury in vivo is becoming more common in the literature. However, there are …

For over a century, axon regeneration has been considered the Holy Grail for spinal cord
injury (SCI) repair. Although there are other factors that could contribute to improving …

Study Design. A literature review was conducted. Objectives. To review animal models and
injury paradigms used in the neurobiologic study of spinal cord regeneration, and to assist …

Axons within the adult mammalian central nervous system do not regenerate spontaneously
after injury. Upon injury, the balance between growth promoting and growth inhibitory factors …

Over the past three decades, tremendous progress has been made in elucidating
mechanisms underlying regenerative failure after spinal cord injury and in devising …

The laboratory mouse has emerged as a primary model organism for studying axon
regeneration after experimental spinal cord injury, owing to its genetic amenability. Mutant …

One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

In the present review we discuss two interrelated events—axonal damage and repair—
known to occur after spinal cord injury (SCI) in the zebrafish. Adult zebrafish are capable of …

Regeneration of injured CNS neurons was once thought to be an unachievable goal. Most
patients with significant damage to the spinal cord suffer from permanently impaired …

ABSTRACT A long-standing goal of spinal cord injury research is to develop effective spinal
cord repair strategies for the clinic. Rat models of spinal cord injury provide an important …