Mouse embryos acquire global DNA methylation of their genome during implantation.
However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been …

During early mammalian embryogenesis, the genome undergoes global epigenetic
reprogramming, losing most of its methylation before re-establishing it de novo at …

Background DNA methylation patterns are initiated by de novo DNA methyltransferases
DNMT3a/3b adding methyl groups to CG dinucleotides in the hypomethylated genome of …

We have previously shown that the DNA methyltransferases Dnmt3a and Dnmt3b carry out
de novo methylation of the mouse genome during early postimplantation development and …

During mammalian development, DNA methylation patterns need to be reset in primordial
germ cells (PGCs) and preimplantation embryos. However, many LTR retrotransposons and …

DNA methylation regulates development and many epigenetic processes in mammals [1],
and it is required for somatic cell growth and survival [2, 3]. In contrast, embryonic stem (ES) …

DNA methylation is extensively reprogrammed during the early phases of mammalian
development, yet genomic targets of this process are largely unknown. We optimized …

DNA methylation is a tightly regulated epigenetic mark associated with transcriptional
repression. Next-generation sequencing of purified methylated DNA obtained from early …

DNA methylation is globally reprogrammed during mammalian preimplantation
development, which is critical for normal development. Recent reduced representation …

Background Normal mammalian development requires the action of DNA
methyltransferases (DNMTs) for the establishment and maintenance of DNA methylation …