Association of environmental toxins with amyotrophic lateral sclerosis

FC Su, SA Goutman, S Chernyak, B Mukherjee… - JAMA …, 2016 - jamanetwork.com
Importance Persistent environmental pollutants may represent a modifiable risk factor
involved in the gene-time-environment hypothesis in amyotrophic lateral sclerosis (ALS) …

Exposure to hazardous air pollutants and the risk of amyotrophic lateral sclerosis

AM Malek, A Barchowsky, R Bowser… - Environmental …, 2015 - Elsevier
Background: Amyotrophic lateral sclerosis (ALS) is a serious and rapidly fatal
neurodegenerative disorder with an annual incidence of 1–2.6/100,000 persons. Few …

Potential environmental factors in amyotrophic lateral sclerosis

B Oskarsson, DK Horton… - Neurologic clinics, 2015 - neurologic.theclinics.com
The causes of amyotrophic lateral sclerosis (ALS) are unknown for most patients. ALS is a
clinically defined syndrome where upper and lower motor neurons degenerate, but The …

Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort

SA Goutman, J Boss, DG Jang, B Mukherjee… - Journal of Neurology …, 2024 - jnnp.bmj.com
Background Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurogenerative
disease caused by combined genetic susceptibilities and environmental exposures …

The amyotrophic lateral sclerosis exposome: recent advances and future directions

SA Goutman, MG Savelieff, DG Jang, J Hur… - Nature Reviews …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neuron degeneration with
typical survival of only 2–5 years from diagnosis. The causes of ALS are multifactorial …

Environmental and occupational exposures and amyotrophic lateral sclerosis in New England

AS Andrew, TA Caller, R Tandan, EJ Duell… - Neurodegenerative …, 2017 - karger.com
Background: Recent data provide support for the concept that potentially modifiable
exposures are responsible for sporadic amyotrophic lateral sclerosis (ALS). Objective: To …

Prospective study of chemical exposures and amyotrophic lateral sclerosis

MG Weisskopf, N Morozova, EJ O'Reilly… - Journal of Neurology …, 2009 - jnnp.bmj.com
Background: Although environmental toxins, including pesticides, are suspected of
contributing to the risk of amyotrophic lateral sclerosis (ALS), no data exist from large …

High plasma concentrations of organic pollutants negatively impact survival in amyotrophic lateral sclerosis

SA Goutman, J Boss, A Patterson… - Journal of Neurology …, 2019 - jnnp.bmj.com
Objective To determine whether persistent organic pollutants (POP) affect amyotrophic
lateral sclerosis (ALS) survival. Methods ALS participants seen at the University of Michigan …

Environmental risk factors and amyotrophic lateral sclerosis (ALS): a case-control study of ALS in Michigan

Y Yu, FC Su, BC Callaghan, SA Goutman… - PloS one, 2014 - journals.plos.org
An interim report of a case-control study was conducted to explore the role of environmental
factors in the development of amyotrophic lateral sclerosis (ALS). Sixty-six cases and 66 age …

Workplace exposures and the risk of amyotrophic lateral sclerosis

F Fang, P Quinlan, W Ye, MK Barber… - Environmental …, 2009 - ehp.niehs.nih.gov
Background Occupation has been suggested to play a role in amyotrophic lateral sclerosis
(ALS) etiology, but detailed information on the importance of specific workplace exposures is …