Regulations of xenobiotics and endobiotics on carboxylesterases: a comprehensive review
Y Xu, C Zhang, W He, D Liu - European journal of drug metabolism and …, 2016 - Springer
Carboxylesterases (CESs) play major roles in catalyzing the hydrolysis of a wide range of
ester-and amide-containing compounds. CESs dominate both the biotransformation of …
ester-and amide-containing compounds. CESs dominate both the biotransformation of …
The impact of carboxylesterases in drug metabolism and pharmacokinetics
L Di - Current drug metabolism, 2019 - ingentaconnect.com
Background: Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters,
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …
Carboxylesterase inhibitors from clinically available medicines and their impact on drug metabolism
YQ Song, Q Jin, DD Wang, J Hou, LW Zou… - Chemico-Biological …, 2021 - Elsevier
Mammalian carboxylesterases (CES), the key members of the serine hydrolase superfamily,
hydrolyze a wide range of endogenous substances and xenobiotics bearing ester or amide …
hydrolyze a wide range of endogenous substances and xenobiotics bearing ester or amide …
Regulation of carboxylesterases and its impact on pharmacokinetics and pharmacodynamics: an up-to-date review
ABSTRACT Introduction Carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …
[HTML][HTML] Human carboxylesterases: a comprehensive review
D Wang, L Zou, Q Jin, J Hou, G Ge, L Yang - Acta Pharmaceutica Sinica B, 2018 - Elsevier
Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …
Carboxylesterases
B Yan - Encyclopedia of drug metabolism and interactions, 2011 - Wiley Online Library
Abstract Carboxylesterases (CESs, EC 3.1. 1.1) constitute a large class of enzymes that
hydrolyze chemicals containing such a functional group as a carboxylic acid ester, amide …
hydrolyze chemicals containing such a functional group as a carboxylic acid ester, amide …
Planarity and constraint of the carbonyl groups in 1, 2-diones are determinants for selective inhibition of human carboxylesterase 1
JL Hyatt, RM Wadkins, L Tsurkan… - Journal of medicinal …, 2007 - ACS Publications
Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of
xenobiotics, including numerous clinically used drugs. Therefore, the selective inhibition of …
xenobiotics, including numerous clinically used drugs. Therefore, the selective inhibition of …
Carboxylesterases-detoxifying enzymes and targets for drug therapy
PM Potter, RM Wadkins - Current medicinal chemistry, 2006 - ingentaconnect.com
Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of
xenobiotics. Many therapeutically useful drugs are metabolized by these proteins which …
xenobiotics. Many therapeutically useful drugs are metabolized by these proteins which …
Keynote review: Mammalian carboxylesterases: From drug targets to protein therapeutics
MR Redinbo, PM Potter - Drug discovery today, 2005 - Elsevier
Our understanding of the detailed recognition and processing of clinically useful therapeutic
agents has grown rapidly in recent years, and we are now able to begin to apply this …
agents has grown rapidly in recent years, and we are now able to begin to apply this …
Different inhibitory effects in rat and human carboxylesterases
S Takahashi, M Katoh, T Saitoh, M Nakajima… - Drug metabolism and …, 2009 - ASPET
In vitro inhibition studies on drug-metabolizing enzyme activity are useful for understanding
drug-drug interactions and for drug development. However, the profile of the inhibitory …
drug-drug interactions and for drug development. However, the profile of the inhibitory …
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