The highly contagious disease tuberculosis (TB) is caused by the bacterium Mycobacterium
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …

Mycobacterium tuberculosis (Mtb) acquires non-heme iron through salicylate-derived
siderophores termed mycobactins whereas heme iron is obtained through a cascade of …

Iron is an essential element to most life forms including mycobacterial species. However, in
the oxidative atmosphere iron exists as insoluble salts. Free and soluble iron ions are scarce …

Iron is essential for nearly all bacterial pathogens, including Mycobacterium tuberculosis
(Mtb), but is severely limited in the human host. To meet its iron needs, Mtb secretes …

Siderophores are small iron-binding molecules secreted by bacteria to scavenge iron.
Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis, produces the …

Mycobacterium tuberculosis must import iron from its host for survival, and its siderophore-
dependent iron acquisition pathways are well established. Here we demonstrate a newly …

Background Elucidation of the basic mechanistic and biochemical principles underlying
siderophore mediated iron uptake in mycobacteria is crucial for targeting this principal …

Iron is an essential nutrient for most bacterial pathogens, but is restricted by the host immune
system. Mycobacterium tuberculosis (Mtb) utilizes two classes of small molecules …

Mycobacterium tuberculosis requires iron for normal growth but faces a limitation of the
metal ion due to its low solubility at biological pH and the withholding of iron by the …

Iron is essential for growth of Mycobacterium tuberculosis (Mtb), but most iron in the human
body is stored in heme within hemoglobin. Here, we demonstrate that the substrate-binding …