Insulin resistance occurs early in the disease process, preceding the development of type 2
diabetes. Therefore, the identification of molecules that contribute to insulin resistance and …

Obesity is a strong risk factor for the development of type 2 diabetes. We have previously
reported that in adipose tissue of obese (ob/ob) mice, the expression of adipogenic genes is …

Development and progression of type 2 diabetes is a complex interaction between genetics
and environmental influences. High dietary fat is one environmental factor that is conducive …

The spontaneously diabetic Goto-Kakizaki (GK) rat is frequently used as a model for human
type 2 diabetes. Selective loss of glucose-sensitive insulin secretion is an early pathogenetic …

Recently, it has been suggested that insulin resistance is a better predictor of metabolic
syndrome than obesity. Numerous studies have been conducted to identify insulin …

Around 9% of the adult population in the world (463 million) suffer from diabetes mellitus.
Most of them (~ 90%) belong to type 2 diabetes mellitus (T2DM), which is a common chronic …

The Goto-Kakizaki (GK) rat, a polygenic non-obese model of type 2 diabetes, is a useful
surrogate for study of diabetes-related changes independent of obesity. GK rats and …

Energy restriction (ER) causes metabolic improvement in the prediabetic and diabetic state.
Little information exists on the mechanism of action of ER, for example, on the changes at …

The inheritance of the tendency to develop diet-induced non-insulin-dependent (type II)
diabetes was analyzed in crosses between diabetes-prone C57BL/6J (BL/6) mice and …

Aims/hypothesis We determined the response of selected genes to in vivo insulin in adipose
tissue in 21 non-diabetic women. Materials and methods The women were divided into …