Salidroside attenuates high‐fat diet‐induced nonalcoholic fatty liver disease via AMPK‐dependent TXNIP/NLRP3 pathway

T Zheng, X Yang, W Li, Q Wang, L Chen… - Oxidative medicine …, 2018 - Wiley Online Library
Our previous studies suggested that salidroside could alleviate hepatic steatosis in type 2
diabetic C57BLKS/Leprdb (db/db) mice. The aim of the present study was to evaluate the …

[HTML][HTML] Auranofin attenuates non-alcoholic fatty liver disease by suppressing lipid accumulation and NLRP3 inflammasome-mediated hepatic inflammation in vivo …

H Hwangbo, MY Kim, SY Ji, SY Kim, H Lee, GY Kim… - Antioxidants, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) causes liver dysfunction and is associated with
obesity and type 2 diabetes. Chronic inflammation is associated not only with the …

NLRP3 inhibitor glibenclamide attenuates high-fat diet and streptozotocin-induced non-alcoholic fatty liver disease in rat: studies on oxidative stress, inflammation …

DK Dwivedi, GB Jena - Naunyn-Schmiedeberg's archives of …, 2020 - Springer
The prevalence of non-alcoholic fatty liver disease (NAFLD) is much higher in diabetic and
obese individuals. Combined exposure of high-fat diet (HFD) and single low-dose …

[HTML][HTML] Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1

Y Zhang, C Geng, X Liu, M Li, M Gao, X Liu, F Fang… - Molecular …, 2017 - Elsevier
Objective Celastrol was recently identified as a potential novel treatment for obesity.
However, the effect of Celastrol on nonalcoholic fatty liver disease (NAFLD) remains elusive …

Trilobatin alleviates non-alcoholic fatty liver disease in high-fat diet plus streptozotocin-induced diabetic mice by suppressing NLRP3 inflammasome activation

ZT Zhang, WJ He, SM Deng, SH Xu, X Zeng… - European Journal of …, 2022 - Elsevier
Diabetes mellitus (DM) is a factor with great risk in the course of non-alcoholic fatty liver
disease (NAFLD) due to its high glucotoxicity and lipotoxicity. Trilobatin, a glycosylated …

Salvianolic acid B ameliorates non-alcoholic fatty liver disease by inhibiting hepatic lipid accumulation and NLRP3 inflammasome in ob/ob mice

LC Meng, JY Zheng, YH Qiu, L Zheng, JY Zheng… - International …, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has high occurrence in the global world, which
poses serious threats to human health. Salvianolic acid B (SalB), an extract of the root of …

Liraglutide ameliorates obesity-related nonalcoholic fatty liver disease by regulating Sestrin2-mediated Nrf2/HO-1 pathway

X Han, C Ding, G Zhang, RY Pan, Y Liu… - Biochemical and …, 2020 - Elsevier
Liraglutide, a glucagon-like peptide 1 (GLP-1) analogue, could reverse NAFLD-induced liver
damage by improving metabolic profiles, but the exact molecular mechanism has not been …

[HTML][HTML] New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats

C Ding, Y Zhao, X Shi, N Zhang, G Zu, Z Li, J Zhou… - Scientific reports, 2016 - nature.com
Salvianolic acid A (SalA), one of the most efficacious polyphenol compounds extracted from
Radix Salvia miltiorrhiza (Danshen), has been shown to possess many potential …

Silymarin alleviates hepatic oxidative stress and protects against metabolic disorders in high-fat diet-fed mice

B Feng, R Meng, B Huang, S Shen, Y Bi… - Free Radical …, 2016 - Taylor & Francis
Silymarin is a potent antioxidant medicine and has been widely used for the treatment of
liver diseases over 30 years. Recent studies suggest that silymarin may benefit patients with …

[HTML][HTML] Diosgenin prevents high-fat diet-induced rat non-alcoholic fatty liver disease through the AMPK and LXR signaling pathways

S Cheng, S Liang, Q Liu, Z Deng… - International …, 2018 - spandidos-publications.com
Non-alcoholic fatty liver disease (NAFLD) is a major public health concern worldwide. The
aim of the present study was to observe the effect of diosgenin on NAFLD and investigate …