Downregulated in adenoma (DRA), also referred to as SLC26A3, is an intestinal anion
transporter essential for intestinal chloride absorption. Mutations in DRA result in congenital …

The down-regulated in adenoma (DRA) gene is significantly down-regulated in adenomas
and adenocarcinomas of the colon as well as in colon cancer cell lines. It is also mutated in …

The pathogenesis of diarrhea in intestinal inflammatory states is a multifactorial process
involving the effects of inflammatory mediators on epithelial transport function. The effect of …

Mutations in the SLC26A3 (DRA (down-regulated in adenoma)) gene constitute the
molecular etiology of congenital chloride-losing diarrhea in humans. To ascertain its role in …

Congenital chloride diarrhea (CLD) is a recessively inherited disorder characterized by
massive loss of chloride in stool. We previously identified mutations in the downregulated in …

The down-regulated in adenoma (DRA) gene was originally identified as a gene that was
down-regulated in colon tumors. It encodes a protein with anion transporter function that is …

Abstract Solute carrier family 26, member 3 (Slc26a3), also termed downregulated-in-
adenoma (DRA) is a member of the Slc26 family of anion transporters and is mutated in …

SLC26A3 [downregulated in adenoma (DRA)] plays a key role in mammalian intestinal NaCl
absorption, in that it mediates apical membrane Cl−/HCO 3− exchange. DRA function and …

A gene has been described, Down Regulated in Adenoma (dra), which is expressed in
normal colon but is absent in the majority of colon adenomas and adenocarcinomas …

SLC26A3, previously named DRA (down-regulatedin-adenoma), is a member of the SLC26
anion transporter family. SLC26A3 is abundantly expressed in the apical membrane of …