The bioactive peptides galanin, spexin and kisspeptin have a common ancestral origin and
their pathophysiological roles are increasingly the subject of investigation. Evidence …

Spexin (SPX) and kisspeptin (KISS) are novel peptides relevant in the context of regulation
of metabolism, food intake, puberty and reproduction. Here, we studied changes of serum …

The novel neuropeptide spexin (SPX) was discovered using bioinformatics. The function of
this peptide is currently under investigation. Here, we identified SPX along with a second …

Kisspeptin was initially identified as a metastasis suppressor. Shortly after the initial
discovery, a key physiologic role for kisspeptin emerged in the regulation of fertility, with …

Aims To investigate the effect of kisspeptin on glucose‐stimulated insulin secretion and
appetite in humans. Materials and methods In 15 healthy men (age: 25.2±1.1 years; BMI …

The novel neuropeptide spexin (SPX) was discovered to activate galanin receptor 2
(GALR2) and 3 (GALR3) but not galanin receptor 1 (GALR1). Although GALR2 is known to …

Apart from the well-established role of kisspeptin (Kp) in the regulation of reproductive
functions, recent data described its action in the control of metabolism. Of particular interest …

Kisspeptin is a neuropeptide with a critical role in the function of the hypothalamic–pituitary–
gonadal (HPG) axis. Kisspeptin is produced by two major populations of neurons located in …

While kisspeptin was initially found to function as a metastasis suppressor, after
identification of its receptor KISS1R and their expression profiles in tissues such as the …

The orexigenic gut peptide ghrelin negatively modulates the hypothalamic–pituitary–
gonadal (HPG) axis. Hyperghrelinaemia results during negative energy balance, a state …