Impact of therapies on bowel damage in Crohn's disease

G Fiorino, C Bonifacio, M Allocca… - United European …, 2020 - journals.sagepub.com
Crohn's disease (CD) is a chronic inflammatory bowel disease that usually progresses to
bowel damage, defined as strictures, fistulas and abscesses. These complications require …

[HTML][HTML] Predictors of bowel damage in the long-term progression of Crohn's disease

A Fernández-Clotet, J Panés, E Ricart… - World Journal of …, 2022 - ncbi.nlm.nih.gov
BACKGROUND Crohn's disease (CD) is a chronic inflammatory bowel disorder that
progresses to bowel damage (BD) over time. An image-based index, the Lémann index (LI) …

Development of the Lémann index to assess digestive tract damage in patients with Crohn's disease

B Pariente, JY Mary, S Danese, Y Chowers, P De Cruz… - Gastroenterology, 2015 - Elsevier
Background & Aims There is a need for a scoring system that provides a comprehensive
assessment of structural bowel damage, including stricturing lesions, penetrating lesions …

Validation and update of the Lémann index to measure cumulative structural bowel damage in Crohn's disease

B Pariente, J Torres, J Burisch, N Arebi, B Barberio… - Gastroenterology, 2021 - Elsevier
Background & Aims The Lémann Index is a tool measuring cumulative structural bowel
damage in Crohn's disease (CD). We reported on its validation and updating. Methods This …

Structural bowel damage in quiescent Crohn's disease

MM Amitai, M Zarchin, A Lahat, D Yablecovitch… - Digestive and Liver …, 2017 - Elsevier
Background Crohn's disease is associated with accumulation of progressive structural
bowel damage (SBD) leading to the development of stenotic and penetrating complications …

The Lemann index—a glance through the window of opportunity?

U Kopylov, R Eliakim - Journal of Crohn's and Colitis, 2017 - academic.oup.com
Crohn's disease [CD] is characterised by a chronic progressive course leading to
accumulation of structural intestinal damage. Up to 60% of CD patients eventually develop …

Prevalence of bowel damage assessed by cross-sectional imaging in early Crohn's disease and its impact on disease outcome

G Fiorino, M Morin, S Bonovas… - Journal of Crohn's …, 2017 - academic.oup.com
Abstract Background and Aims: Bowel damage in Crohn's disease [CD] is defined as the
presence of intestinal strictures, fistulas or abscesses. Early disease may represent a …

Beyond remission and mucosal healing in Crohn's disease. Exploring the deep with cross sectional imaging

G Maconi, A Armuzzi - Digestive and Liver Disease, 2017 - dldjournalonline.com
The targets of therapy in inflammatory bowel disease (IBD) have changed in recent years. A
growing body of evidence has shown that biologics allow treating beyond the symptoms …

Anti-TNF therapy is able to stabilize bowel damage progression in patients with Crohn's disease. A study performed using the Lémann Index

G Bodini, EG Giannini, C De Maria, P Dulbecco… - Digestive and Liver …, 2017 - Elsevier
Aims The Lémann Index (LI) was developed to assess the cumulative structural damage of
the intestinal tract in patients with Crohn's Disease (CD) independently of clinical and …

Bowel damage assessment in Crohn's disease by magnetic resonance imaging

G Fiorino, L Peyrin-Biroulet, S Danese - Current Drug Targets, 2012 - ingentaconnect.com
Crohn's disease leads to complications in the majority of patients on the long term.
Strictures, fistulas and abscesses usually involve the bowel wall or extra-intestinal …