Gap junction channels made of different connexins have distinct permeability to second
messengers, which could affect many cell processes, including lens epithelial cell division …

Gap junction channels mediate the direct intercellular passage of small ions as well as
larger solutes such as second messengers. A family of proteins called connexins make up …

Purpose: Gap junction channels exhibit connexin specific biophysical properties, including
the selective intercellular passage of larger solutes, such as second messengers. Here, we …

Gap junctions formed of connexin46 (Cx46) and connexin50 (Cx50) in lens fiber cells are
crucial for maintaining lens transparency. We determined the functional properties of …

Lens fiber cell gap junctions contain α3 (Cx46) and α8 (Cx50) connexins. To examine the
roles of the two different connexins in lens physiology, we have genetically engineered mice …

Connexins are a family of proteins that can form two distinct types of channels:
hemichannels and gap junction channels. Hemichannels are composed of six connexin …

Gap junction channels formed by connexin 50 (Cx50) are critical for maintenance of lens
transparency. Because the C-terminus of Cx50 can be cleaved post-translationally, we …

Gap junction channels formed by connexin50 (Cx50) are critical for maintenance of eye lens
transparency. Cleavage of the carboxyl terminus (CT) of Cx50 to produce truncated Cx50 …

Gap junctions are composed of proteins called connexins (Cx) and facilitate both ionic and
biochemical modes of intercellular communication. In the lens, Cx46 and Cx50 provide the …

The differentiation of mouse lens epithelial cells into fiber cells is a useful model for studying
the changes of the electrical properties of gap junction (cell-to-cell) channels that are …