Th17 cells have been casually associated to the pathogenesis of autoimmune disease. We
have previously demonstrated that Rai/ShcC, a member of the Shc family of adaptor …

Rai prevents lupus nephritis by impairing the development and expansion of both
proinflammatory Th17 and Th1 cells. Rai, a Shc adapter family member, acts as a negative …

Multiple sclerosis is an autoimmune disease caused by autoreactive immune cell infiltration
into the central nervous system leading to inflammation, demyelination, and neuronal loss …

Pathogenic Th17 cells are critically involved in many autoimmune diseases, while non-
pathogenic Th17 cells are more immune regulatory. Understanding the mechanisms of the …

Reactive astrocytes are a hallmark of neurodegenerative disease including multiple
sclerosis. It is widely accepted that astrocytes may adopt alternative phenotypes depending …

Dysregulation of Th17 cell differentiation and pathogenicity contributes to multiple
autoimmune and inflammatory diseases. Previously growth hormone releasing hormone …

Signal regulatory protein α (SIRPα) is expressed predominantly on type 2 conventional
dendritic cells (cDC2s) and macrophages. We previously showed that mice systemically …

Autoreactive CD4 T cells that differentiate into pathogenic Th17 cells can trigger
autoimmune diseases. Therefore, investigating the regulatory network that modulates Th17 …

T‐cell activation RhoGTPase‐activating protein (TAGAP) is a GTPase‐activating protein
specific for RhoA that is exclusively expressed in activated T cells. Genome‐wide …

Abstract Interleukin‐1 (IL‐1) is implicated in numerous pathologies, including multiple
sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE) …