[HTML][HTML] Special Issue “flavonoids and their disease prevention and treatment potential”: Recent advances and future perspectives

HPV Rupasinghe - Molecules, 2020 - mdpi.com
In recent years, the interest in flavonoids as dietary bioactives to prevent human diseases,
as well as their candidacy as pharmaceutical leads, has exponentially expanded …

Natural products targeting tumour angiogenesis

X Lu, LJ Friedrich, T Efferth - British journal of pharmacology, 2023 - Wiley Online Library
Tumour angiogenesis is the formation of new blood vessels to support the growth of a
tumour. This process is critical for tumour progression and metastasis, making it an attractive …

Potential of natural flavonoids to target breast cancer angiogenesis

Y Wang, M Huang, X Zhou, H Li, X Ma… - British Journal of …, 2023 - Wiley Online Library
Angiogenesis is the process by which new blood vessels form and is required for tumour
growth and metastasis. It helps in supplying oxygen and nutrients to tumour cells and plays …

Differential suppression of intracellular reactive oxygen species-mediated signaling pathway in vascular endothelial cells by several subclasses of flavonoids

L Yi, C Chen, X Jin, T Zhang, Y Zhou, Q Zhang, J Zhu… - Biochimie, 2012 - Elsevier
Increased intracellular reactive oxygen species (ROS) is crucial for vascular endothelial
dysfunction, a key step in the initiating of atherosclerosis (AS). The antioxidant activity of …

Flavonoids: As omnipotent candidates for cancer management

P Chand, H Kumar, R Jain, A Jain, V Jain - South African Journal of Botany, 2023 - Elsevier
The development of the cancer is a complex process as it proliferates, alters the signaling
pathways, and ultimately reduced the patient's survival. The altered cellular events and …

Flavonoids as a scaffold for development of novel anti-angiogenic agents: An experimental and computational enquiry

RN Gacche, RJ Meshram, HD Shegokar… - Archives of biochemistry …, 2015 - Elsevier
Relationship between structural diversity and biological activities of flavonoids has remained
an important discourse in the mainstream of flavonoid research. In the current study anti …

[HTML][HTML] Flavonoids as vasorelaxant agents: synthesis, biological evaluation and quantitative structure activities relationship (QSAR) studies

X Dong, Y Wang, T Liu, P Wu, J Gao, J Xu, B Yang… - Molecules, 2011 - mdpi.com
A series of 2-(2-diethylamino)-ethoxychalcone and 6-prenyl (or its isomers)-flavanones 10a,
b and 11a–g were synthesized and evaluated for their vasorelaxant activities against rat …

Pathophysiology of atherosclerosis: Association of risk factors and treatment strategies using plant‐based bioactive compounds

H Sharif, MSH Akash, K Rehman… - Journal of Food …, 2020 - Wiley Online Library
Under physiological conditions, endothelial cells act as protective barrier which prevents
direct contact of blood with circulating factors via production of tissue plasminogen activator …

Insights into dietary flavonoids as molecular templates for the design of anti-platelet drugs

B Wright, JPE Spencer, JA Lovegrove… - Cardiovascular …, 2013 - academic.oup.com
Flavonoids are low-molecular weight, aromatic compounds derived from fruits, vegetables,
and other plant components. The consumption of these phytochemicals has been reported …

[HTML][HTML] Impact of specific functional groups in flavonoids on the modulation of platelet activation

D Ravishankar, M Salamah, A Akimbaev… - Scientific reports, 2018 - nature.com
Flavonoids exert innumerable beneficial effects on cardiovascular health including the
reduction of platelet activation, and thereby, thrombosis. Hence, flavonoids are deemed to …