A genome-scale metabolic model of Bacillus megaterium WSH002, an industrial bacterium
widely used in the vitamin C industry, was reconstructed on the basis of the genome …

Background Metabolic reconstruction is the computational-based process that aims to
elucidate the network of metabolites interconnected through reactions catalyzed by activities …

Genetic variation is the motor of evolution and allows organisms to overcome the
environmental challenges they encounter. It can be both beneficial and harmful in the …

Optimizing the metabolic pathways of microbial cell factories is essential for establishing
viable biotechnological production processes. However, due to the limited understanding of …

Background Thermus thermophilus, an extremely thermophilic bacterium, has been widely
recognized as a model organism for studying how microbes can survive and adapt under …

Genome-scale models (GEMs) of bacterial strains' metabolism have been formulated and
used over the past 20 years. Recently, with the number of genome sequences exponentially …

Yarrowia lipolytica is a widely-used chassis cell in biotechnological applications. It has
recently gained extensive research interest owing to its extraordinary ability of producing …

Background Zymomonas mobilis ZM4 is a Gram-negative bacterium that can efficiently
produce ethanol from various carbon substrates, including glucose, fructose, and sucrose …

A genome‐scale metabolic model of the Gram‐positive bacteria Corynebacterium
glutamicum ATCC 13032 was constructed comprising 446 reactions and 411 metabolites …

Mathematical modeling is an essential tool for the comprehensive understanding of cell
metabolism and its interactions with the environmental and process conditions. Recent …