Objective Previous studies demonstrated that deficiency of angiotensin-converting enzyme 2
(ACE2) augmented angiotensin II (AngII)-induced atherosclerosis and abdominal aortic …

A growing body of evidence suggests that the vascular actions of Ang‐(1‐7) appear to
involve increased production of nitric oxide (NO), an important vasodilator, through the …

Objective—Angiotensin-converting enzyme 2 (ACE2) cleaves angiotensin II (AngII) to form
angiotensin-(1–7)(Ang-(1–7)), which generally opposes effects of AngII. AngII infusion into …

We explored the roles of angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7), and
Mas activation in angiotensin II type 1 receptor blockade-mediated attenuation of vascular …

Objective—Angiotensin II (AngII) has been shown to regulate angiogenesis and at high
pathophysiological doses to cause vasoconstriction through the AngII receptor type 1 …

Mas codes for a G protein–coupled receptor that is implicated in angiotensin-(1-7) signaling.
We studied the cardiovascular phenotype of Mas-deficient mice backcrossed onto the FVB/N …

The Mas gene codes for an angiotensin (1-7) receptor. There is accumulating evidence that
Mas is involved in vascular homeostasis. We have recently backcrossed Mas-knockout mice …

Background Endothelial dysfunction is an initial step in the pathogenesis of cardiovascular
diseases. Since we previously identified the G protein-coupled receptor Mas as a receptor …

AT 1 antagonists effectively prevent atherosclerosis since AT 1 upregulation and
angiotensin II-induced proinflammatory actions are critical to atherogenesis. Despite the …

Angiotensin-(1–7)[ANG-(1–7)] acts at Mas receptors (MasR) to oppose effects of angiotensin
II (ANG II). Previous studies demonstrated that protection of female mice from obesity …