[HTML][HTML] Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice

J Stegbauer, SE Thatcher, G Yang, K Bottermann… - Journal of vascular …, 2019 - Elsevier
Objective Previous studies demonstrated that deficiency of angiotensin-converting enzyme 2
(ACE2) augmented angiotensin II (AngII)-induced atherosclerosis and abdominal aortic …

Increased aortic intimal proliferation due to MasR deletion in vitro

H Alsaadon, P Kruzliak, A Smardencas… - International journal …, 2015 - Wiley Online Library
A growing body of evidence suggests that the vascular actions of Ang‐(1‐7) appear to
involve increased production of nitric oxide (NO), an important vasodilator, through the …

Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II–induced abdominal aortic aneurysms

SE Thatcher, X Zhang, DA Howatt… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Angiotensin-converting enzyme 2 (ACE2) cleaves angiotensin II (AngII) to form
angiotensin-(1–7)(Ang-(1–7)), which generally opposes effects of AngII. AngII infusion into …

Possible involvement of angiotensin-converting enzyme 2 and Mas activation in inhibitory effects of angiotensin II Type 1 receptor blockade on vascular remodeling

M Iwai, H Nakaoka, I Senba, H Kanno, T Moritani… - …, 2012 - Am Heart Assoc
We explored the roles of angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7), and
Mas activation in angiotensin II type 1 receptor blockade-mediated attenuation of vascular …

Mechanisms of Mas1 receptor-mediated signaling in the vascular endothelium

BR Hoffmann, TJ Stodola, JR Wagner… - … , and vascular biology, 2017 - Am Heart Assoc
Objective—Angiotensin II (AngII) has been shown to regulate angiogenesis and at high
pathophysiological doses to cause vasoconstriction through the AngII receptor type 1 …

Endothelial Dysfunction and Elevated Blood Pressure in Mas Gene-Deleted Mice

P Xu, AC Costa-Goncalves, M Todiras, LA Rabelo… - …, 2008 - Am Heart Assoc
Mas codes for a G protein–coupled receptor that is implicated in angiotensin-(1-7) signaling.
We studied the cardiovascular phenotype of Mas-deficient mice backcrossed onto the FVB/N …

Ablation of angiotensin (1-7) receptor Mas in C57Bl/6 mice causes endothelial dysfunction

LA Rabelo, P Xu, M Todiras, WO Sampaio… - Journal of the American …, 2008 - Elsevier
The Mas gene codes for an angiotensin (1-7) receptor. There is accumulating evidence that
Mas is involved in vascular homeostasis. We have recently backcrossed Mas-knockout mice …

Endothelial dysfunction through genetic deletion or inhibition of the G protein-coupled receptor Mas: a new target to improve endothelial function

C Peiró, S Vallejo, F Gembardt, V Azcutia… - Journal of …, 2007 - journals.lww.com
Background Endothelial dysfunction is an initial step in the pathogenesis of cardiovascular
diseases. Since we previously identified the G protein-coupled receptor Mas as a receptor …

MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular angiotensin-converting enzyme 2–angiotensin-(1-7) …

L Pernomian, AF do Prado, MS Gomes… - European Journal of …, 2015 - Elsevier
AT 1 antagonists effectively prevent atherosclerosis since AT 1 upregulation and
angiotensin II-induced proinflammatory actions are critical to atherogenesis. Despite the …

Differential effects of Mas receptor deficiency on cardiac function and blood pressure in obese male and female mice

Y Wang, R Shoemaker, D Powell… - American Journal …, 2017 - journals.physiology.org
Angiotensin-(1–7)[ANG-(1–7)] acts at Mas receptors (MasR) to oppose effects of angiotensin
II (ANG II). Previous studies demonstrated that protection of female mice from obesity …