Abstract Angiotensin (Ang)-(1-7) ameliorates vascular injury by increasing nitric oxide (NO)
bioavailability. Evidence that Ang-(1-7) attenuates the development of atherosclerosis …

Abstract Angiotensin‐converting enzyme‐2 (ACE2) and Mas receptor are the major
components of the ACE2/Ang 1‐7/Mas axis and have been shown to play a protective role in …

OBJECTIVE: Chymase may play an important role in abdominal aortic aneurysm (AAA)
development through matrix metalloproteinase (MMP)-9 activation. The purpose of this study …

In this study we investigated the effects of the genetic deletion of the angiotensin (Ang)-(1-7)
receptor Mas on heart function. Localization of Mas in the mouse heart was evaluated by …

Abstract Activation of the angiotensin 1–7/Mas receptor (MasR) axis counteracts angiotensin
II (Ang II)-mediated cardiovascular disease. Recombinant human angiotensin-converting …

Apolipoprotein E–deficient (apoE (−/−)) mice fed on Western diet are characterized by
increased vascular resistance and atherosclerosis. Previously, we have shown that chronic …

The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in the regulation of
physiological homeostasis and diseases such as hypertension, coronary artery disease and …

The heptapeptide angiotensin-(1–7)(Ang-(1–7)) is protective in the cardiovascular system
through its induction of vasodilator production and angiogenesis. Despite acting …

Background Statins reduce aneurysm growth in mouse models of Marfan syndrome,
although the mechanism is unknown. In addition to reducing cholesterol, statins block …

Objective—The renin-angiotensin system contributes to atherosclerotic lesion formation.
Angiotensin-converting enzyme 2 (ACE2) catabolizes angiotensin II (Ang II) to angiotensin 1 …