Systemic sclerosis is an uncommon autoimmune connective tissue disease with multiorgan
system involvement and significant associated morbidity and mortality. Cutaneous signs and …

Several effective drugs have been identified for the treatment of systemic sclerosis (SS c).
However, in advanced cases, not only their effectiveness is reduced but they may be also …

The management of systemic sclerosis (SSc) is complex, evolving, and requires a
multidisciplinary approach. At diagnosis and throughout the disease course, clinical …

Systemic sclerosis is a complex chronic disease characterised by chronic multisystem
involvement of skin and internal organs. We reviewed all the articles published during the …

Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by
severe and often progressive cutaneous and visceral fibrosis, pronounced alterations in the …

Systemic sclerosis (SSc) is an autoimmune disease and a disabling condition that reduces
life expectancy. Disease heterogeneity is a hallmark of SSc and classification has been hard …

Systemic sclerosis is a connective tissue disorder that affects multiple organs. Although the
initial symptoms of the disease are vascular, skin involvement is almost universally present …

Systemic sclerosis is the rheumatic disease with the highest individual mortality. The severity
of the disease is determined by the extent of fibrotic changes to cutaneous and internal …

Systemic sclerosis affects the connective tissue of various organs. It is characterized by
alteration of the microvasculature with a dense inflammatory cellular infiltrate, followed by …

Systemic sclerosis remains a challenging disease despite progress that has taken place in
the management of organbased complications. Overall management strategies need to take …