APOPTOSIS AND PARAPTOSIS, INVOLVING ENDOPLASMIC RETICULUM STRESS, AUTOPHAGY AND MITOCHONDRIAL DYSFUNCTION, ARE INDUCED BY …
F Fontana - 2020 - air.unimi.it
Castration resistant prostate cancer (CRPC) is the most aggressive form of prostate cancer
with still limited therapeutic outcomes due to the development of resistance to standard …
with still limited therapeutic outcomes due to the development of resistance to standard …
Mitochondrial functional and structural impairment is involved in the antitumor activity of δ-tocotrienol in prostate cancer cells
F Fontana, M Raimondi, M Marzagalli… - Free Radical Biology …, 2020 - Elsevier
The therapeutic options for castration-resistant prostate cancer (CRPC) are still limited.
Natural bioactive compounds were shown to possess pro-death properties in different …
Natural bioactive compounds were shown to possess pro-death properties in different …
δ‐Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells
F Fontana, RM Moretti, M Raimondi… - Cell …, 2019 - Wiley Online Library
Objectives Prostate cancer, after the phase of androgen dependence, may progress to the
castration‐resistant prostate cancer (CRPC) stage, with resistance to standard therapies …
castration‐resistant prostate cancer (CRPC) stage, with resistance to standard therapies …
Ca2+ overload- and ROS-associated mitochondrial dysfunction contributes to δ-tocotrienol-mediated paraptosis in melanoma cells
M Raimondi, F Fontana, M Marzagalli, M Audano… - Apoptosis, 2021 - Springer
Melanoma is an aggressive tumor with still poor therapy outcomes. δ-tocotrienol (δ-TT) is a
vitamin E derivative displaying potent anti-cancer properties. Previously, we demonstrated …
vitamin E derivative displaying potent anti-cancer properties. Previously, we demonstrated …
Ca2+ overload-and ROS-associated mitochondrial dysfunction contributes to δ-tocotrienol-mediated paraptosis in melanoma cells
R Michela, F Fabrizio, M Monica… - Apoptosis: An …, 2021 - search.proquest.com
Melanoma is an aggressive tumor with still poor therapy outcomes. δ-tocotrienol (δ-TT) is a
vitamin E derivative displaying potent anti-cancer properties. Previously, we demonstrated …
vitamin E derivative displaying potent anti-cancer properties. Previously, we demonstrated …
Necroptosis Induced by Delta-Tocotrienol Overcomes Docetaxel Chemoresistance in Prostate Cancer Cells
M Montagnani Marelli, G Beretta… - International Journal of …, 2023 - mdpi.com
Prostate cancer (PCa) represents the fifth cause of cancer death in men. Currently,
chemotherapeutic agents for the treatment of cancers, including PCa, mainly inhibit tumor …
chemotherapeutic agents for the treatment of cancers, including PCa, mainly inhibit tumor …
δ‐Tocotrienol sensitizes and re‐sensitizes ovarian cancer cells to cisplatin via induction of G1 phase cell cycle arrest and ROS/MAPK‐mediated apoptosis
F Fontana, M Marzagalli, M Raimondi, V Zuco… - Cell …, 2021 - Wiley Online Library
Objectives Among gynaecologic malignancies, ovarian cancer (OC) represents the leading
cause of death for women worldwide. Current OC treatment involves cytoreductive surgery …
cause of death for women worldwide. Current OC treatment involves cytoreductive surgery …
Tocotrienols modulate a life or death decision in cancers
Malignancy often arises from sophisticated defects in the intricate molecular mechanisms of
cells, rendering a complicated molecular ground to effectively target cancers. Resistance …
cells, rendering a complicated molecular ground to effectively target cancers. Resistance …
[HTML][HTML] Synergistic anticancer activity of resveratrol in combination with docetaxel in prostate carcinoma cells
SH Lee, YJ Lee - Nutrition research and practice, 2021 - synapse.koreamed.org
RESULTS At concentrations not toxic to normal human prostate epithelial cells, resveratrol
effectively decreased the viability of LNCaP cells depending on concentration and time. The …
effectively decreased the viability of LNCaP cells depending on concentration and time. The …
Alpha-tocopheryl succinate inhibits autophagic survival of prostate cancer cells induced by vitamin K3 and ascorbate to trigger cell death
M Tomasetti, L Nocchi, J Neuzil, J Goodwin, M Nguyen… - PloS one, 2012 - journals.plos.org
Background The redox-silent vitamin E analog α-tocopheryl succinate (α-TOS) was found to
synergistically cooperate with vitamin K3 (VK3) plus ascorbic acid (AA) in the induction of …
synergistically cooperate with vitamin K3 (VK3) plus ascorbic acid (AA) in the induction of …