A case of extensive protein platination: The reaction of lysozyme with a Pt (II)–terpyridine complex
An antiproliferative platinum (II)–terpyridine complex bearing two piperidine substituents at
positions 2 and 2′(compound 1, hereafter) interacts non-covalently with DNA and induces …
positions 2 and 2′(compound 1, hereafter) interacts non-covalently with DNA and induces …
Platinum-based drugs and proteins: reactivity and relevance to DNA adduct formation
O Pinato, C Musetti, NP Farrell, C Sissi - Journal of inorganic biochemistry, 2013 - Elsevier
The mechanism of action of clinically used Pt-based drugs is through the formation of stable
DNA adducts occurring at the nitrogen in position 7 of guanine (N7) and involving one or two …
DNA adducts occurring at the nitrogen in position 7 of guanine (N7) and involving one or two …
Insights into the molecular mechanisms of protein platination from a case study: the reaction of anticancer platinum (II) iminoethers with horse heart cytochrome C
The interactions of anticancer metallodrugs with proteins are attracting a growing interest in
the current literature because of their relevant pharmacological and toxicological …
the current literature because of their relevant pharmacological and toxicological …
Peculiar Features in the Crystal Structure of the Adduct Formed between cis-PtI2(NH3)2 and Hen Egg White Lysozyme
The reactivity of cis-diamminediiodidoplatinum (II), cis-PtI2 (NH3) 2, the iodo analogue of
cisplatin, with hen egg white lysozyme (HEWL) was investigated by electrospray ionization …
cisplatin, with hen egg white lysozyme (HEWL) was investigated by electrospray ionization …
Pt-based drugs: the spotlight will be on proteins
O Pinato, C Musetti, C Sissi - Metallomics, 2014 - academic.oup.com
Platinum-complexes represent some of the most successful groups of clinically used
anticancer drugs. Their mechanism of action relies on the formation of stable DNA adducts …
anticancer drugs. Their mechanism of action relies on the formation of stable DNA adducts …
Reaction with proteins of a five-coordinate platinum (ii) compound
Stable five-coordinate Pt (II) complexes have been highlighted as a promising and original
platform for the development of new cytotoxic drugs. Their interaction with proteins has been …
platform for the development of new cytotoxic drugs. Their interaction with proteins has been …
Interactions between Anticancer trans-Platinum Compounds and Proteins: Crystal Structures and ESI-MS Spectra of Two Protein Adducts of trans-(Dimethylamino) …
The adducts formed between trans-(dimethylamino)(methylamino) dichloridoplatinum (II),[t-
PtCl2 (dma)(ma)], and two model proteins, ie, hen egg white lysozyme and bovine …
PtCl2 (dma)(ma)], and two model proteins, ie, hen egg white lysozyme and bovine …
Picoplatin binding to proteins: X-ray structures and mass spectrometry data on the adducts with lysozyme and ribonuclease A
The reactivity of the anticancer drug picoplatin (cis-amminedichlorido (2-methylpyridine)
platinum (II) complex) with the model proteins hen egg white lysozyme (HEWL) and bovine …
platinum (II) complex) with the model proteins hen egg white lysozyme (HEWL) and bovine …
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme
A Casini, G Mastrobuoni, C Temperini… - Chemical …, 2006 - pubs.rsc.org
The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with
hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting …
hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting …
Reactions of cisplatin and cis-[PtI2 (NH3) 2] with molecular models of relevant protein sidechains: A comparative analysis
Quite surprisingly, cisplatin and cis-[PtI 2 (NH 3) 2] were found to manifest significant
differences in their reactions with the model protein lysozyme. We decided to explore …
differences in their reactions with the model protein lysozyme. We decided to explore …