Background Wnt/β-catenin signaling pathway is closely related to osteoarthritis. In our
preliminary study, β-catenin conditional activation (cAct) mice that specifically over-express …

Objective Osteoarthritis is a degenerative joint disease whose molecular mechanism is
currently unknown. Wnt/β‐catenin signaling has been demonstrated to play a critical role in …

Abstract Purpose of Review Arthritis defines a large group of diseases primarily affecting the
joint. It is the leading cause of pain and disability in adults. Osteoarthritis (OA) affecting the …

Summary Objective The canonical Wnt signaling pathway has been shown to be involved in
regulating chondrocyte hypertrophic differentiation during Osteoarthritis (OA). The aim of this …

Cartilaginous endplate degeneration serves a key role in the process of intervertebral disc
(IVD) degeneration, however, effective therapies are hindered by an incomplete …

Objective The incidence of low back pain is extremely high and is often linked to
intervertebral disc (IVD) degeneration. The mechanism of this disease is currently unknown …

Osteoarthritis (OA) is a degenerative joint disease, and the mechanism of its pathogenesis is
poorly understood. Recent human genetic association studies showed that mutations in the …

Osteoarthritis (OA) is a degenerative joint disease involving both cartilage and synovium.
The canonical Wnt/β-catenin pathway, which is activated in OA, is emerging as an important …

Objective The results of recent animal studies suggest that activation of Wnt/β‐catenin
signaling in articular chondrocytes might be a driving factor in the pathogenesis of …

Wnt5a signalling plays pathological roles in synovial inflammation and bone destruction. In
the present study, we designed four human Wnt5a-based DNA recombinants and detected …