It is not the most intellectual of the species that survives; it is not the strongest that survives;
but the species that survives is the one that is able best to adapt and adjust to the changing …

Purpose Fluorouracil/leucovorin as the sole therapy for metastatic colorectal cancer (CRC)
provides an overall survival of 8 to 12 months. With an increase in surgical resections of …

For patients with metastatic colon cancer, management has evolved from resecting a single
liver metastasis and having only one chemotherapy medicine, to resecting multiple …

Asymptomatic patients with metastatic colorectal cancer do not routinely need to undergo
resection of the primary tumor. Although several retrospective analyses suggest that patients …

Context: The treatment of colorectal cancer has improved considerably in recent years, but it
remains the second commonest cause of cancer deaths in men and women in the United …

Purpose: New chemotherapy agents and integrated treatments have improved the
prognosis of patients with metastatic colorectal cancer. Methods: From January 2000 to …

Despite recent advances in the medical treatment of metastatic colorectal cancer (mCRC),
which include irinotecan-and oxaliplatin-based first-line regimens, the concept of planned …

Historically, the setting of liver-limited metastases from CRC has been one of the few
examples of curative metastasectomy in oncology. Even before the development of effective …

Metastatic colorectal cancer remains a public-health issue on a global scale. With
development of a new generation of cytotoxic agents, survival has improved for patients with …

Background. Metastatic colorectal cancer has a poor prognosis, and the majority of patients
are left with palliative measures. The development seen using medical treatments are …