[HTML][HTML] PITX2 upregulation increases the risk of chronic atrial fibrillation in a dose-dependent manner by modulating IKs and ICaL—insights from human atrial …
Background Functional analysis has shown that the paired-like homeodomain transcription
factor 2 (PITX2) overexpression associated with atrial fibrillation (AF) leads to the slow …
factor 2 (PITX2) overexpression associated with atrial fibrillation (AF) leads to the slow …
[HTML][HTML] Mechanisms underlying pro-arrhythmic abnormalities arising from Pitx2-induced electrical remodelling: An in silico intersubject variability study
Background Electrical remodelling as a result of the homeodomain transcription factor 2
(Pitx2)-dependent gene regulation induces atrial fibrillation (AF) with different mechanisms …
(Pitx2)-dependent gene regulation induces atrial fibrillation (AF) with different mechanisms …
[HTML][HTML] In silico investigation of the mechanisms underlying atrial fibrillation due to impaired Pitx2
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is a major cause
of stroke and morbidity. Recent genome-wide association studies have shown that paired …
of stroke and morbidity. Recent genome-wide association studies have shown that paired …
[HTML][HTML] Understanding PITX2-dependent atrial fibrillation mechanisms through computational models
Atrial fibrillation (AF) is a common arrhythmia. Better prevention and treatment of AF are
needed to reduce AF-associated morbidity and mortality. Several major mechanisms cause …
needed to reduce AF-associated morbidity and mortality. Several major mechanisms cause …
[HTML][HTML] Proarrhythmia in the p. Met207Val PITX2c-linked familial atrial fibrillation-insights from modeling
Functional analysis has shown that the p. Met207Val mutation was linked to atrial fibrillation
and caused an increase in transactivation activity of PITX2c, which caused changes in …
and caused an increase in transactivation activity of PITX2c, which caused changes in …
In silico assessment of genetic variation in PITX2 reveals the molecular mechanisms of calcium-mediated cellular triggered activity in atrial fibrillation
Genome-wide association studies have identified genetic variants including rs13143308T in
the homeobox gene Pitx2 associated with atrial fibrillation (AF) populations. However, the …
the homeobox gene Pitx2 associated with atrial fibrillation (AF) populations. However, the …
PITX2 Knockout Induces Key Findings of Electrical Remodeling as Seen in Persistent Atrial Fibrillation
C Schulz, MD Lemoine, G Mearini… - Circulation …, 2023 - Am Heart Assoc
Background: Electrical remodeling in human persistent atrial fibrillation is believed to result
from rapid electrical activation of the atria, but underlying genetic causes may contribute …
from rapid electrical activation of the atria, but underlying genetic causes may contribute …
Pitx2c increases in atrial myocytes from chronic atrial fibrillation patients enhancing IKs and decreasing ICa,L
M Perez-Hernandez, M Matamoros… - Cardiovascular …, 2016 - academic.oup.com
Aims Atrial fibrillation (AF) produces rapid changes in the electrical properties of the atria
(electrical remodelling) that promote its own recurrence. In chronic AF (CAF) patients, up …
(electrical remodelling) that promote its own recurrence. In chronic AF (CAF) patients, up …
[HTML][HTML] Ablation and antiarrhythmic drug effects on PITX2+/− deficient atrial fibrillation: A computational modeling study
Z Jin, I Hwang, B Lim, OS Kwon, JW Park… - Frontiers in …, 2022 - frontiersin.org
Introduction: Atrial fibrillation (AF) is a heritable disease, and the paired-like homeodomain
transcription factor 2 (PITX2) gene is highly associated with AF. We explored the differences …
transcription factor 2 (PITX2) gene is highly associated with AF. We explored the differences …
[HTML][HTML] Pitx2c deficiency confers cellular electrophysiological hallmarks of atrial fibrillation to isolated atrial myocytes
Aims Atrial fibrillation (AF) has been associated with altered expression of the transcription
factor Pitx2c and a high incidence of calcium release-induced afterdepolarizations …
factor Pitx2c and a high incidence of calcium release-induced afterdepolarizations …